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論文

COEファカルティの業績


平松啓一

1. Ito, T., Okuma, K., Ma, X.X., Yuzawa, H., and Hiramatsu, K. 2003. Insights on Antibiotic Resistance of Staphylococcus aureus from its Whole Genome: Genomic Island SCC. Drug Res. Updates. 6: 41-52.

2. Cui, L., Ma, X., Sato, K., Okuma, K., Tenover, F. C., Mamizuka, E. M., Gemmell, C. G., Kim, M-N., Ploy, M-C., Solh, N. E., Ferraz, V., and Hiramatsu, K. 2003. Cell Wall Thickening Is a Common Feature of Vancomycin Resistance in Staphylococcus aureus. J. Clin. Microbiol.41:5-14.

3. Yoshida, R., Kuwahara-Arai, Baba, T., Cui, L., Richardson, J. F., and K. Hiramatsu. 2003. Physiological and molecular analysis of a mecA-negative Staphylococcus aureus clinical strain that expresses heterogeneous methicillin resistance J Antimicrob Chemother 51:247-255.

4. Katayama, Y., Takeuchi, F., Ito, T., Ma1, X. X., Ui-Mizutani , Y., Kobayashi, I., and Hiramatsu, K. 2003. Identification in a methicillin-susceptible Staphylococcus hominis of an active primordial mobile genetic element for the staphylococcal cassette chromosome mec (SCCmec) of methicillin-resistant Staphylococcus aureus. J. Bacteriol. 185:2711-2722.

5. Isnansetyo, A., Cui, L., Hiramatsu, K., and Kamei, Y. 2003. Antibacterial activity of 2,4-diacetylphloroglucinol (DAPG) produced by Pseudomonas sp. AMSN isolated from a marine alga, against vancomycin-resistant Staphylococcus aureus (VRSA). Int J Antimicrob Agents 22:545-7.

6. Kuroda, M., Kuroda, H., Oshima, T., Takeuchi, F., Mori, H., and Hiramatsu, K. 2003. Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus. Molecular Microbiol. 49: 807-821.

7. Cui, L., and K. Hiramatsu. 2004. Vancomycin-resistant Staphylococcus aureus. in ed, by Franz-Josef Schmitz and Dr. Ad C. Fluit. MRSA. Horizon Scientific Press.

8. Kuroda, M., and K. Hiramatsu. 2004. Genome sequencing and annotation: an overview in Johnson, A., and Woodford, N., ed., Genomics, Proteomics and Clinical Bacteriology. Humana Press.

9. Baba, T.,Takeuchi, F., Kuroda, M., Yuzawa, H., Ito, T., and Hiramatsu, K. 2004. The Genome of Staphylococcus aureus. pp In Al’Aladeen, D., and Hiramatsu, K (ed). The Staphylococcus aureus: Molecular and Clinical Aspects. Eliis Harwood, London, UK.

10. Hiramatsu, K. (2004). Elucidation of the mechanism of antibiotic resistance acquisition of methicillin-resistant Staphylococcus aureus (MRSA) and determination of its whole genome nucleotide sequence. Jap Med Assoc J. in press

11. Hiramatsu, K., Kuroda, M., Baba, T., and K. Okuma. 2004. Application of Genomic Information to the Diagnosis, Management and Control of Bacterial Infections: The Staphylococcus aureus model In ed.by D. Persing, et al. Diagnostic Molecular Microbiology 2nd Ed, pp407-418, ASM Press.

青木孝

1. Aoki T (2003) Metabolism of parasitic protozoa. In: Progress of Medical Parasitology in Japan, Vol. 7, edited by M Otsuru et al. Chapter III. Megro Parasitological Museum, Tokyo, pp.175-191

2. Asaruddin MR, Honda G, Tsubouchi A, Nakajima-Shimada J, Aoki T, Kiuchi F (2003) Trypanocidal constituents from Michelia alba. Natural Medicines, 57, 61-63

3. Takamiya S, Yamasaki H, Hashimoto M, Taka H, Murayama K, Tagaya M, Aoki T (2003) Heterologous expression of Ascaris suum cytochrome b5 precursor protein: a histidine-tagged full-length presequence is correctly processed to transport the mature protein to the periplasm of Escherichia coli. Arch Biochem Biophys, 413, 253-261

4. Amino H, Osanai A, Miyadera H, Shinjyo N, Tomitsuka E, Taka H, Mineki R, Murayama K, Takamiya S, Aoki T, Miyoshi H, Sakamoto K, Kojima S, Kita K (2003) Isolation and characterization of the stage-specific cytochrome b small subunit (CybS) of Ascaris suum complex II from the aerobic respiratory chain of larval mitochondria. Mol Biochem Parasitol, 128, 175-186.

5. Nara T, Hirayama-Noguchi Y, Gao G, Murai E, Annoura T, Aoki T (2003) Diversity of aspartate carbamoyltransferase genes of Trypanosoma cruzi. Int J Parasitol, 33, 845-852

6. Miyahira Y, Katae M, Takeda K, Yagita H, Okumura K, Kobayashi S, Takeuchi T, Kamiyama T, Fukuchi Y, Aoki T (2003) Activation of natural killer T cells by α-galactosylceramide impairs DNA vaccine-induced protective immunity against Trypanosoma cruzi. Infect Immun, 71, 1234-1241

7. Miyahira Y, Katae M, Kobayashi S, Takeuchi T, Fukuchi Y, Abe R, Okumura K, Yagita H, Aoki T (2003) Critical contribution of CD28-CD80/CD86 costimulatory pathway to protection from Trypanosoma cruzi infection. Infect Immun, 71, 3131-3137

Miyahira Y, Akiba H, Katae M, Kubota K, Kobayashi S, Takeuchi T, Garcia-Sastre A, Fukuchi Y, Okumura K, Yagita H, Aoki T (2003)Cutting edge: a potent adjuvant effect of ligand to receptor activator of NF-kappa B gene for inducing antigen-specific CD8+ T cell response by DNA and viral vector vaccination. J Immunol, 171, 6344-6348

Hirota K, Tsubouchi A, N.-Shimada J,NaraT, Aoki T (2004)Inhibition of Trypanosoma cruzi growth in mammalian cells by nimodipine, with low cytotoxicity to host cells. Trop Med Health, 32, 181-188

Annoura T, Nara T, Makiuchi T, Hashimoto T, Aoki T (2004)The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions. J Mol Evol, 59, 1-15

池田志斈

1. Ikeda S, Kawada J, Yaguchi H, Ogawa H: A case of unilateral, systematized linear hair follicle nevi associated with epidermal nevus-like lesions. Dermatology, 206: 172-4, 2003

2. Ikeda S, Imamura S, Hashimoto I, Morioka S, Sakuma M, Ogawa H: History of the establishment and revision of diagnostic criteria, severity index and therapeutic guidelines for pemphigus in Japan. Arch Dermatol Res, 295: S12-6, 2003

3. Tamai K, Hashimoto I, Hanada K, Ikeda S, Imamura S, Ogawa H: Japanese guidelines for diagnosis and treatment of junctional and dystrophic epidermolysis bullosa. Arch Dermatol Res, 295: S24-8, 2003

4. Umezawa Y, Ozawa A, Kawasima T, Shimizu H, Terui T, Tagami H, Ikeda S, Ogawa H, Kawada A, Tezuka T, Igarashi A, Harada S: Therapeutic guidelines for the treatment of generalized pustular psoriasis (GPP) based on a proposed classification of disease severity. Arch Dermatol Res, 295: S43-54, 2003

5. Ikeda S, Komiyama E, Ogawa H: The prognosis of pemphigus patients will be significantly improved in the future. Arch Dermatol Res, 295: S69-70, 2003

6. Muramatsu S, Kimura T, Ueki R, Tsuboi R, Ikeda S, Ogawa H: Recurrent E413K Mutation of hHb6 in a Japanese Family with Monilethrix. Dermatology, 206: 338-40, 2003

7. Aronchik I, Behne MJ, Leypoldt L, Crumrine D, Epstein Jr EH, Ikeda S, Mizoguchi M, Bench G, Pozzan T, Mauro T: Actin Reorganization is Abnormal in Hailey-Hailey Disease Keratinocytes, Due to Decreases in Cellular ATP. J Invest Dermatol, 121: 681-7, 2003.

8. Ikeda S, Mayuzumi N, Shigihara T, Epstein Jr EH, Goldsmith LA, Ogawa H: Mutations in ATP2A2 in Patients with Darier’s Disease. J Invest Dermatol, 121: 475-7, 2003.

9. Wongpiyabovorn J, Suto H, Ushio H, Izuhara K, Mitsuishi K, Ikeda S, Nakao A, Okumura K, Ogawa H: Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis. J Dermatol Sci. 33: 31-40, 2003.

10. Hasegawa T, Suga Y, Mizoguchi M, Ikeda S, Ogawa H, Kubo K, Matsui H, Kagawa S, Kuroyanagi Y: Clinical tryal of allogeneic cultured dermal substitute for the treatment of intractable skin ulcers in three patients with recessive dystrophic epidermolysis bullosa. J Am Acad Dermatol, 2004, in press.

奥村康

1. Akizawa, Y., C. Nishiyama, M. Hasegawa, K. Maeda, T. Nakahata, K. Okumura, C. Ra, and H. Ogawa. 2003. Regulation of human FcepsilonRI beta chain gene expression by Oct-1. Int Immunol 15:549-556.

2. Aramaki, O., N. Shirasugi, Y. Akiyama, S. Shibutani, T. Takayama, M. Shimazu, M. Kitajima, Y. Ikeda, K. Okumura, H. Yagita, and M. Niimi. 2003. CD27/CD70, CD134/CD134 ligand, and CD30/CD153 pathways are independently essential for generation of regulatory cells after intratracheal delivery of alloantigen. Transplantation 76:772-776.

3. Dan, N., T. Kanai, T. Totsuka, R. Iiyama, M. Yamazaki, T. Sawada, T. Miyata, H. Yagita, K. Okumura, and M. Watanabe. 2003. Ameliorating effect of anti-Fas ligand MAb on wasting disease in murine model of chronic colitis. Am J Physiol Gastrointest Liver Physiol 285:G754-760.

4. Funaki, T., A. Nakao, N. Ebihara, Y. Setoguchi, Y. Fukuchi, K. Okumura, C. Ra, H. Ogawa, and A. Kanai. 2003. Smad7 suppresses the inhibitory effect of TGF-beta2 on corneal endothelial cell proliferation and accelerates corneal endothelial wound closure in vitro. Cornea 22:153-159.

5. Hasegawa, M., C. Nishiyama, M. Nishiyama, Y. Akizawa, K. Mitsuishi, T. Ito, H. Kawada, S. Furukawa, C. Ra, K. Okumura, and H. Ogawa. 2003. A novel -66T/C polymorphism in Fc epsilon RI alpha-chain promoter affecting the transcription activity: possible relationship to allergic diseases. J Immunol 171:1927-1933.

6. Hasegawa, M., C. Nishiyama, M. Nishiyama, Y. Akizawa, K. Takahashi, T. Ito, S. Furukawa, C. Ra, K. Okumura, and H. Ogawa. 2003. Regulation of the human Fc epsilon RI alpha-chain distal promoter. J Immunol 170:3732-3738.

7. Hoshino, A., Y. Tanaka, H. Akiba, Y. Asakura, Y. Mita, T. Sakurai, A. Takaoka, S. Nakaike, N. Ishii, K. Sugamura, H. Yagita, and K. Okumura. 2003. Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma. Eur J Immunol 33:861-869.

8. Iwai, H., M. Abe, S. Hirose, F. Tsushima, K. Tezuka, H. Akiba, H. Yagita, K. Okumura, H. Kohsaka, N. Miyasaka, and M. Azuma. 2003. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J Immunol 171:2848-2854.

9. Kanai, T., T. Totsuka, K. Uraushihara, S. Makita, T. Nakamura, K. Koganei, T. Fukushima, H. Akiba, H. Yagita, K. Okumura, U. Machida, H. Iwai, M. Azuma, L. Chen, and M. Watanabe. 2003. Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. J Immunol 171:4156-4163.

10. Kanamaru, Y., A. Nakao, Y. Tanaka, Y. Inagaki, H. Ushio, I. Shirato, S. Horikoshi, K. Okumura, H. Ogawa, and Y. Tomino. 2003. Involvement of p300 in TGF-beta/Smad-pathway-mediated alpha2(I) collagen expression in mouse mesangial cells. Nephron Exp Nephrol 95:e36-42.

11. Kirii, Y., T. Inoue, K. Yoshino, N. Kayagaki, H. Yagita, K. Okumura, H. Shibata, Y. Yoshikawa, and K. Terao. 2003. Molecular cloning, functional characterization, and enzyme-linked immunosorbent assay of cynomolgus monkey Fas ligand. J Immunol Methods 278:201-209.

12. Maeda, K., C. Nishiyama, T. Tokura, Y. Akizawa, M. Nishiyama, H. Ogawa, K. Okumura, and C. Ra. 2003. Regulation of cell type-specific mouse Fc epsilon RI beta-chain gene expression by GATA-1 via four GATA motifs in the promoter. J Immunol 170:334-340.

13. Miura, Y., N. Misawa, Y. Kawano, H. Okada, Y. Inagaki, N. Yamamoto, M. Ito, H. Yagita, K. Okumura, H. Mizusawa, and Y. Koyanagi. 2003. Tumor necrosis factor-related apoptosis-inducing ligand induces neuronal death in a murine model of HIV central nervous system infection. Proc Natl Acad Sci U S A 100:2777-2782.

14. Miyahira, Y., H. Akiba, M. Katae, K. Kubota, S. Kobayashi, T. Takeuchi, A. Garcia-Sastre, Y. Fukuchi, K. Okumura, H. Yagita, and T. Aoki. 2003. Cutting edge: a potent adjuvant effect of ligand to receptor activator of NF-kappa B gene for inducing antigen-specific CD8+ T cell response by DNA and viral vector vaccination. J Immunol 171:6344-6348.

15. Miyahira, Y., H. Akiba, S.H. Ogawa, T. Ishi, S. Watanabe, S. Kobayashi, T. Takeuchi, T. Aoki, K. Tezuka, R. Abe, K. Okumura, H. Yagita, and N. Watanabe. 2003. Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections. Immunol Lett 89:193-199.

16. Miyahira, Y., M. Katae, S. Kobayashi, T. Takeuchi, Y. Fukuchi, R. Abe, K. Okumura, H. Yagita, and T. Aoki. 2003. Critical contribution of CD28-CD80/CD86 costimulatory pathway to protection from Trypanosoma cruzi infection. Infect Immun 71:3131-3137.

17. Miyahira, Y., M. Katae, K. Takeda, H. Yagita, K. Okumura, S. Kobayashi, T. Takeuchi, T. Kamiyama, Y. Fukuchi, and T. Aoki. 2003. Activation of natural killer T cells by alpha-galactosylceramide impairs DNA vaccine-induced protective immunity against Trypanosoma cruzi. Infect Immun 71:1234-1241.

18. Muto, T., S.D. Hsieh, Y. Sakurai, H. Yoshinaga, H. Suto, K. Okumura, and H. Ogawa. 2003. Prevalence of atopic dermatitis in Japanese adults. Br J Dermatol 148:117-121.

19. Nakayama, M., N. Harada, K. Okumura, and H. Yagita. 2003. Characterization of murine TWEAK and its receptor (Fn14) by monoclonal antibodies. Biochem Biophys Res Commun 306:819-825.

20. Nakayama, M., K. Ishidoh, Y. Kojima, N. Harada, E. Kominami, K. Okumura, and H. Yagita. 2003. Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. J Immunol 170:341-348.

21. Nishiyama, C., T. Yokota, M. Nishiyama, C. Ra, K. Okumura, and H. Ogawa. 2003. Molecular cloning of rat transcription factor YY1. Biosci Biotechnol Biochem 67:654-658.

22. Okazaki, T., S. Sakon, T. Sasazuki, H. Sakurai, T. Doi, H. Yagita, K. Okumura, and H. Nakano. 2003. Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses. Biochem Biophys Res Commun 300:807-812.

23. Sakon, S., X. Xue, M. Takekawa, T. Sasazuki, T. Okazaki, Y. Kojima, J.H. Piao, H. Yagita, K. Okumura, T. Doi, and H. Nakano. 2003. NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. Embo J 22:3898-3909.

24. Shirasugi, N., Y. Akiyama, O. Aramaki, S. Shibutani, K. Matsumoto, H. Bashuda, H. Yagita, K. Okumura, Y. Ikeda, and M. Niimi. 2003. Role of the CTLA4 pathway in hyporesponsiveness induced by intratracheal delivery of alloantigen. Transplantation 75:1636-1639.

25. Sumiyoshi, K., A. Nakao, Y. Setoguchi, K. Okumura, R. Tsuboi, and H. Ogawa. 2003. Smads regulate collagen gel contraction by human dermal fibroblasts. Br J Dermatol 149:464-470.

26. Sumiyoshi, K., A. Nakao, Y. Setoguchi, R. Tsuboi, K. Okumura, and H. Ogawa. 2003. TGF-beta/Smad signaling inhibits IFN-gamma and TNF-alpha-induced TARC (CCL17) production in HaCaT cells. J Dermatol Sci 31:53-58.

27. Tajima, A., T. Tanaka, T. Ebata, K. Takeda, A. Kawasaki, J.M. Kelly, P.K. Darcy, R.E. Vance, D.H. Raulet, K. Kinoshita, K. Okumura, M.J. Smyth, and H. Yagita. 2003. Blastocyst MHC, a putative murine homologue of HLA-G, protects TAP-deficient tumor cells from natural killer cell-mediated rejection in vivo. J Immunol 171:1715-1721.

28. Totsuka, T., T. Kanai, K. Uraushihara, R. Iiyama, M. Yamazaki, H. Akiba, H. Yagita, K. Okumura, and M. Watanabe. 2003. Therapeutic effect of anti-OX40L and anti-TNF-alpha MAbs in a murine model of chronic colitis. Am J Physiol Gastrointest Liver Physiol 284:G595-603.

29. Totsuka, T., T. Kanai, R. Iiyama, K. Uraushihara, M. Yamazaki, R. Okamoto, T. Hibi, K. Tezuka, M. Azuma, H. Akiba, H. Yagita, K. Okumura, and M. Watanabe. 2003. Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis. Gastroenterology 124:410-421.

30. Tsuji, H., S. Kawaguchi, T. Wada, S. Nagoya, M. Inobe, H. Yagita, K. Okumura, T. Yamashita, and T. Uede. 2003. Concurrent induction of T-cell activation and apoptosis of osteosarcoma cells by adenovirus-mediated B7-1/Fas chimeric gene transfer. Cancer Gene Ther 10:717-725.

31. Tsushima, F., H. Iwai, N. Otsuki, M. Abe, S. Hirose, T. Yamazaki, H. Akiba, H. Yagita, Y. Takahashi, K. Omura, K. Okumura, and M. Azuma. 2003. Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses. Eur J Immunol 33:2773-2782.

32. Uno, K., T. Inukai, N. Kayagaki, K. Goi, H. Sato, A. Nemoto, K. Takahashi, K. Kagami, N. Yamaguchi, H. Yagita, K. Okumura, T. Koyama-Okazaki, T. Suzuki, K. Sugita, and S. Nakazawa. 2003. TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells. Blood 101:3658-3667.

33. Warnnissorn, P., A. Nakao, H. Suto, H. Ushio, N. Yamaguchi, H. Yagita, K. Okumura, and H. Ogawa. 2003. Tumour necrosis factor-related apoptosis-inducing ligand expression in atopic dermatitis. Br J Dermatol 148:829-831.

34. Wongpiyabovorn, J., H. Suto, H. Ushio, K. Izuhara, K. Mitsuishi, S. Ikeda, A. Nakao, K. Okumura, and H. Ogawa. 2003. Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis. J Dermatol Sci 33:31-40.

35. Yoshimoto, T., B. Min, T. Sugimoto, N. Hayashi, Y. Ishikawa, Y. Sasaki, H. Hata, K. Takeda, K. Okumura, L. Van Kaer, W.E. Paul, and K. Nakanishi. 2003. Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice. J Exp Med 197:997-1005.

長岡功

1. TsuTsumi-Ishii Y, Nagaoka I: Modulation of human β-defensin-2 (hBD-2) transcription in pulmonary epithelial cells by LPS-stimulated mononuclear phagocytes via pro-inflammatory cytokine production. J Immunol 170: 4226-4236, 2003

2. Ohwada A, Yoshioka Y, Iwabuchi K, Nagaoka I, Dambara T, Fukuchi Y.: VEGF regulates the proliferation of acid-exposed alveolar lining epithelial cells. Thorax 58: 328-332, 2003

3. Ohwada A, Tsutsumi-Ishii Y, Yoshioka Y, Iwabuchi K, Nagaoka I, Fukuchi Y.: Acid exposure potentiates intercellular adhesion molecule-1 and e-cadherin expression on A549 alveolar lining epithelial cells. Exp. Lung Res. 29: 389-400, 2003

4. Enomoto F, Kin R, Kataoka T, Yamazaki Y, Yokoi H, Fujimori M, Nagaoka I, Ichikawa G.: Modulation of neutrophil adhesion to vascular endothelial cells in rat experimental otitis media treated with a macrolide. Auris Nasus Larynx. 30: 247-51, 2003

5. Niyonsaba F, Hirata M, Ogawa H, Nagaoka I: Epithelial cell-derived antibacterial peptides human β-defensins and cathelicidin-multifunctional activities on mast cells. Curr Drug Targets Inflamm Allergy 2: 224-231, 2003

広瀬幸子

1. Kobayashi M, Kimura H, Liao J, Abe M, Hirose S, Tomino Y. Measurement of mouse urinary typeIV collagen using time-resolved fluoroimmunoassay. Anal Science, 19:205-210, 2003

2. Nakamura K, Xiu Y, Ohtsuji M, Sugita G, Abe M, Ohtsuji N, Hamano Y, Jiang Y, Takahashi N, Shirai T, Nishimura H, Hirose S. Genetic dissection of anxiety in autoimmune disease. Hum Mol Genet, 12:1079-1086, 2003

3. Fujimura S, Kuwahara K, Ezaki T, Tomita K, Hirose S, Sakaguchi N. Spontaneous increase of plasma-like cells with high GAMP expression in the extrafollicular region of lymphoid organs of autoimmune-prone mice. Autoimmunity, 20:291-301, 2003

4. Matsuoka S, Tsurui H, Abe M, Terashima K, Nakamura K, Hamano Y, Ohtsuji M, Honma N, Serizawa I, Ishii Y, Takiguchi M. Hirose S, Shirai T. A monoclonal antibody to the α2 domain of murine major histocompatibility complex class I that specifically kills activated lymphocytes and blocks liver damage in the concanavalin A hepatitis model. J Exp Med, 198:497-503, 2003

5. Iwai H, Abe M, Hirose S, Tsushima F, Tezuka K, Akiba H, Yagita H, Okumura K, Miyasaka N, Azuma M. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J Immunol, 171:2848-2854, 2003

6. Tsushima F, Iwai H, Otsuki N, Abe M, Hirose S, Yamazaki T, Akiba H, Yagita H, Takahashi Y, Omura K, Okumura K, Azuma M: Preferential contribution of B7-H1 to programmed death―1mediated regulation of hapten-specific allergic inflammatory responses. Eur J Immunl, 33:2773-2782, 2003

7. Li N, Nakamura K, Jiang Y, Tsurui H, Matsuoka S, Abe M, Ohtsuji M, Nishimura H, Kato K, Kawai T, Atsumi T, Koike T, Shirai T, Ueno H, Hirose S: Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. Hum Mol Genet, 13:171-179, 2004

8. Wen X, Zhang D, Kikuchi Y, Jiang Y, Nakamura K, Xiu Y, Tsurui H, Takahashi K, Abe M, Ohtsuji M, Nishimura H, Takatsu K, Shirai T, Hirose S: Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease, but increases the risk of B-cell chronic lymphocytic leukemia in a model of murine lupus. Eur J Immunol, 34:2740-2749, 2004.

9. Zhang D, Fujio K, Jiang Y, Zhao J, Tada N, Sudo K, Tsurui H, Nakamura K, Yamamoto K, Nishimura H, Shirai T, Hirose S: Dissection of the role of MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination. Proc Natl Acad Sci USA, 101:13838-13843, 2004.

10. Miyai K, Furugen Y, Matsumoto T, Iwabuchi K, Hirose S, Kinoshita K, Fujii H: Loss of heterozygosity analysis in uterine cervical adenocarcinoma. Gynecol Oncol, 94:115-20, 2004

11. Takahashi F, Tsuta K, Matsuno Y, Takahashi K, Sato K, Uekusa T, Izumi H, Nakamura K, Hirose S, Fukuchi Y. Adenocarcinoma of the thymus: mucous subtype. Human Pathol. In press.

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