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Juntendo University
Graduate School of Medicine
Center of Excellence for
Infection Control Science
Keiichi Hiramatsu, M.D., Ph.D.
TEL 81-(0)3-5802-1040
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Publication

Publications of the COE faculty.


Keiichi Hiramatsu

1. Ito, T., Okuma, K., Ma, X.X., Yuzawa, H., and Hiramatsu, K. 2003. Insights on Antibiotic Resistance of Staphylococcus aureus from its Whole Genome: Genomic Island SCC. Drug Res. Updates. 6: 41-52.

2. Cui, L., Ma, X., Sato, K., Okuma, K., Tenover, F. C., Mamizuka, E. M., Gemmell, C. G., Kim, M-N., Ploy, M-C., Solh, N. E., Ferraz, V., and Hiramatsu, K. 2003. Cell Wall Thickening Is a Common Feature of Vancomycin Resistance in Staphylococcus aureus. J. Clin. Microbiol.41:5-14.

3. Yoshida, R., Kuwahara-Arai, Baba, T., Cui, L., Richardson, J. F., and K. Hiramatsu. 2003. Physiological and molecular analysis of a mecA-negative Staphylococcus aureus clinical strain that expresses heterogeneous methicillin resistance J Antimicrob Chemother 51:247-255.

4. Katayama, Y., Takeuchi, F., Ito, T., Ma1, X. X., Ui-Mizutani , Y., Kobayashi, I., and Hiramatsu, K. 2003. Identification in a methicillin-susceptible Staphylococcus hominis of an active primordial mobile genetic element for the staphylococcal cassette chromosome mec (SCCmec) of methicillin-resistant Staphylococcus aureus. J. Bacteriol. 185:2711-2722.

5. Isnansetyo, A., Cui, L., Hiramatsu, K., and Kamei, Y. 2003. Antibacterial activity of 2,4-diacetylphloroglucinol (DAPG) produced by Pseudomonas sp. AMSN isolated from a marine alga, against vancomycin-resistant Staphylococcus aureus (VRSA). Int J Antimicrob Agents¡¡22:545-7.

6. Kuroda, M., Kuroda, H., Oshima, T., Takeuchi, F., Mori, H., and Hiramatsu, K. 2003. Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus. Molecular Microbiol. 49: 807-821.

7. Hiramatsu K, Kuroda M, Baba T, and Okuma. 2003. Application of Genomic Information to the Diagnosis, Management and Control of Bacterial Infections: The Staphylococcus aureus model Diagnostic Molecular Microbiology 2nd Ed, pp407-418, ed.by D. Persing, et al., ASM Press

8. Cui, L., and K. Hiramatsu. 2004. Vancomycin-resistant Staphylococcus aureus. in ed, by Franz-Josef Schmitz and Dr. Ad C. Fluit. MRSA. Caister Academic Press.

9. Kuroda, M., and K. Hiramatsu. 2004. Genome sequencing and annotation: an overview in Johnson, A., and Woodford, N., ed., Genomics, Proteomics and Clinical Bacteriology. Humana Press.

10. Baba, T.,Takeuchi, F., Kuroda, M., Yuzawa, H., Ito, T., and Hiramatsu, K. 2004. The Genome of Staphylococcus aureus. pp In Al'Aladeen, D., and Hiramatsu, K (ed). The Staphylococcus aureus: Molecular and Clinical Aspects. Eliis Harwood, London, UK.

11. Hiramatsu, K. 2004. Elucidation of the mechanism of antibiotic resistance acquisition of methicillin-resistant Staphylococcus aureus (MRSA) and determination of its whole genome nucleotide sequence. Jap Med Assoc 47(4): 153. V159.

12. Hiramatsu, K., Kuroda, M., Baba, T., and K. Okuma. 2004. Application of Genomic Information to the Diagnosis, Management and Control of Bacterial Infections: The Staphylococcus aureus model In ed.by D. Persing, et al. Diagnostic Molecular Microbiology 2nd Ed, pp407-418, ASM Press.

13. Ito T, Ma XX, Takeuchi F, Okuma K, Yuzawa H, Hiramatsu K. 2004. Novel type V staphylococcal cassette chromosome mec driven by a novel cassette chromosome recombinase, ccrC. Antimicrob Agents Chemother. Jul;48(7):2637-51.

14. Wang JL, Tseng SP, Hsueh PR, Hiramatsu K. 2004. Vancomycin heteroresistance in methicillin-resistant Staphylococcus aureus, Taiwan. Emerg Infect Dis. Sep;10(9):1702-4.

15. Song JH, Hiramatsu K, Suh JY, Ko KS, Ito T, Kapi M, Kiem S, Kim YS, Oh WS, Peck KR, Lee NY. 2004. Asian Network for Surveillance of Resistant Pathogens Study Group. Emergence in Asian countries of Staphylococcus aureus with reduced susceptibility to vancomycin. Antimicrob Agents Chemother. Dec;48(12):4926-8.

16. Hiramatsu K, Cui L, Kuwahara-Arai K. 2004. Has vancomycin-resistant Staphylococcus aureus started going it alone? Lancet. Aug 14;364(9434):565-6.

17. Nagaoka I, Kuwahara-Arai K, Tamura H, Hiramatsu K, Hirata M. 2005. Augmentation of the bactericidal activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by amino acid substitutions. Inflamm Res. Feb;54(2):66-73.

18. Sng LH, Koh TH, Wang GC, Hsu LY, Kapi M, Hiramatsu K. 2005. Heterogeneous vancomy cin-resistant Staphylococcus aureus (hetero-VISA) in Singapore. Int J Antimicrob Agents. Feb;25(2):177-9.

19. Watanabe S, Ito T, Takeuchi F, Endo M, Okuno E, Hiramatsu K. 2005. Structural comparison of ten serotypes of staphylocoagulases in Staphylococcus aureus. J Bacteriol Jun;187(11):3698-707.

20. Ma XX, Galiana A, Pedreira W, Mowszowicz M, Christophersen I, Machiavello S, Lope L, Benaderet S, Buela F, Vincentino W, Albini M, Bertaux O, Constenla I, Bagnulo H, Llosa L, Ito T, Hiramatsu K. 2005. Community-acquired methicillin-resistant Staphylococcus aureus, Uruguay. Emerg Infect Dis. 11(6):973-6.

21. Hisata K, Kuwahara-Arai K, Yamamoto M, Ito T, Nakatomi Y, Cui L, Baba T, Terasawa M, Sotozono C, Kinoshita S, Yamashiro Y, Hiramatsu K. 2005. Dissemination of methicillin-resistant staphylococci among healthy Japanese children. J Clin Microbiol Jul;43(7):3364-72.

22. Torun MM, Bahar H, Demirci M, Altas K, Bagdatli Y, Kocazeybek B, Kapi M, Hiramatsu K. 2005. Two heterogeneously vancomycin-intermediate clinical isolates of methicillin-sensitive and methicillin-resistant Staphylococcus aureus in a Turkish university hospital: brief report of a surveillance study. Int J Antimicrob Agents. Dec;26(6):508-10.

23. Soo Ko K, Peck KR, Sup Oh W, Lee NY, Hiramatsu K, Song JH. 2005. Genetic differentiation of methicillin-resistant Staphylococcus aureus strains from Korea and Japan. Microb Drug Resist. Fall;11(3):279-86.

24. Cui L, Lian JQ, Neoh HM, Reyes E, Hiramatsu K. 2005. DNA microarray-based identification of genes associated with glycopeptide resistance in Staphylococcus aureus. Antimicrob Agents Chemother. Aug;49(8):3404-13.

25. Ogata M, Tutumimoto Sato K, Kunikane T, Oka K, Seki M, Urano S, Hiramatsu K, Endo T. 2005. Antibacterial activity of dipropofol and related compounds. Biol Pharm Bull. Jun;28(6):1120-2.

26. Noguchi N, Suwa J, Narui K, Sasatsu M, Ito T, Hiramatsu K, Song JH. 2005. Susceptibilities to antiseptic agents and distribution of antiseptic-resistance genes qacA/B and smr of methicillin-resistant Staphylococcus aureus isolated in Asia during 1998 and 1999. J Med Microbiol. Jun;54(Pt 6):557-65.

27. Takeuchi F, Watanabe S, Baba T, Yuzawa H, Ito T, Morimoto Y, Kuroda M, Cui L, Takahashi M, Ankai A, Baba S, Fukui S, Lee JC, Hiramatsu K. 2005. Whole-genome sequencing of staphylococcus haemolyticus uncovers the extreme plasticity of its genome and the evolution of human-colonizing staphylococcal species.J Bacteriol. Nov;187(21):7292-308.

28. Feng-Jui Chen, Tsai-Ling Lauderdale, I-Wen Huang, Hsiu-Jung Lo, Jui-Fen Lai, Hui-Yin Wang, Yih-Ru Shiau, Pei-Chen Chen, Teruyo Ito, and Keichii Hiramatsu. 2005. Methicillin-resistant Staphylococcus aureus in Taiwan. Emerg Infect Dis November 11( 5 ).

29. Ito T, Hiramatsu K. 2005. Nucleic acid-based testing for methicillin-resistant Staphylococcus aureus infection. Nippon Rinsho. Dec;63 Suppl 12:378-86.

30. Hiramatsu K, Kapi M, Tajima Y, Cui L, Trakulsomboon S, and Ito T. 2005. Advance in vancomycin-resistance research in Staphylococcus aureus. Frontiers in Antimicrobial Resistance: a Tribute to Stuart B. Levy ; Editors: Alekshun M, McDermott P, and White D. Amer Society for Microbiology. Chapt 21, p289-298. August.

31. Cui L, Tominaga E, Neoh Hui-min, and Hiramatsu K. 2006. Correlation between Reduced Daptomycin Susceptibility and Vancomycin Resistance in Vancomycin-Intermediate Staphylococcus aureus. Antimicrob Agents Chemother March Vol 50(3), 1079 - 1082.

32. Cui L, Iwamoto A, Lian J-Q, Neoh Hui-min, Maruyama T, Horikawa Y and Hiramatsu K. 2006. Novel Mechanism of Antibiotic Resistance Originating in Vancomycin-Intermediate Staphylococcus aureus. Antimicrob Agents Chemother Feb;50(2):428-38.

33. Chongtrakool P, Ito T, Ma XX, Kondo Y, Trakulsomboon S, Tiensasitorn C, Jamklang M, Chavalit T, Song JH, Hiramatsu K. 2006. Staphylococcal cassette chromosome mec (SCCmec) typing of methicillin-resistant Staphylococcus aureus strains isolated in 11 Asian countries: a proposal for a new nomenclature for SCCmec elements. Antimicrob Agents Chemother Mar;50(3):1001-12.

34. Ma XX, Ito T, Chongtrakool P, Hiramatsu K. 2006. Predominance of clones carrying Panton-Valentine leukocidin genes among methicillin-resistant Staphylococcus aureus strains isolated in Japanese hospitals from 1979 to 1985. J Clin Microbiol. 2006 Dec;44(12):4515-27. Epub 2006 Oct 18.

35. Bae T, Baba T, Hiramatsu K, Schneewind O. 2006. Prophages of Staphylococcus aureus Newman and their contribution to virulence. Mol Microbiol. Nov;62(4):1035-47.

36. Lian JQ, Cui L, Hiramatasu K. 2006. Influence of mgrA overexpression on oxacillin resistance in staphylococcus aureus. Chin J Microbiol Immunol ; Vol.26 (7), 603-609.

37. Bakri F, Abu A, Shehabi A, Naffa R, Cui L, Hiramatsu K. 2007. Persistent bacteremia due to methicillin resistant Staphylococcus aureus with reduced susceptibility to vancomycin in a patient with erythrodermic psoriasis. Scand J Infect Dis. 2007;39(5):457-60.

38. Kondo Y, Ito T, Ma XX, Watanabe S, Kreiswirth BN, Etienne J, Hiramatsu K. 2007. Combination of multiplex PCRs for SCCmec type assignment: Rapid identification system for mec, ccr, and major differences in junkyard regions. Antimicrob Agents Chemother. 2007 Jan;51(1):264-74.

39. Watanabe S, Ito T, Morimoto Y, Takeuchi F, Hiramatsu K. 2007. Precise excision and self-integration of a composite transposon as a model for spontaneous large-scale chromosome inversion/deletion of the Staphylococcus haemolyticus clinical strain JCSC1435. J Bacteriol. Apr;189(7):2921-5. Epub 2007 Jan 19.

40. Kuroda H, Kuroda M, Cui L, Hiramatsu K. 2007. Subinhibitory concentrations of beta-lactam induce haemolytic activity in Staphylococcus aureus through the SaeRS two-component system. FEMS Microbiol Lett. Mar;268(1):98-105.

41. Sasaki T, Kikuchi K, Tanaka Y, Takahashi N, Kamata S, Hiramatsu K. 2007. Methicillin-Resistant Staphylococcus pseudintermedius in a Veterinary Teaching Hospital. J Clin Microbiol. Apr;45(4):1118-25. Epub 2007 Jan 31.

42. Sasaki T, Kikuchi K, Tanaka Y, Takahashi N, Kamata S, Hiramatsu K. 2007. Reclassification of phenotypically identified staphylococcus intermedius strains. J Clin Microbiol. Sep;45(9):2770-8.

43. Tajima Y, Komatsu K. Ito T. Hiramatsu K. 2007. Rapid detection of Staphylococcus aureus strains having reduced susceptibility to vancomycin using a chemiluminescence-based drug-susceptibility test. J Microbiol Methods. 2007 Sep;70(3):434-41. Epub Jun 14.

44. Watanabe S, Ito T, Hiramats K. 2007. Susceptibilities of healthcare- and community-associated methicillin-resistant staphylococci to the novel des-F(6)-quinolone DX-619. J Antimicrob Chemother. Dec;60(6):1384-7.

45. Ito T, Kuwahara K, Hiramatsu K. 2007. Staphylococcal cassette chromosome mec(SCC mec) analysis of MRSA. Methods Mol Biol. 2007;391:87-102.

46. Takeuchi F, Baba T, Hiramatsu K. 2007. Comparative analysis of MRSA. Methods Mol Biol. 2007;391:153-68.

47. Neoh HM, Hori S, Komatsu M, Oguri T, Takeuchi F, Cui L, Hiramatsu K. 2007. Impact of reduced vancomycin susceptibility on the therapeutic outcome of MRSA bloodstream infections. Ann Clin Microbiol Antimicrob. 2007 Oct 30;6:13.

48. Ichikawa S, Ishihara M, Okazaki T, Warabi K, Kato Y, Hori S, Lane GJ, Hiramatsu K, Inada E, Kobayashi H, Yamataka A. 2007. Prospective Study of Antibiotic Protocols for Managing Surgical Site Infections in Children. J Pediatr Surg. 2007 Jun;42(6):1002-7; discussion 1007.

49. Rashel M, Uchiyama J, Ujihara T, Uehara Y, Kuramoto S, Sugihara S, Yagyu K, Muraoka A, Sugai M, Hiramatsu K, Honke K, Matsuzaki S. 2007. Efficient elimination of multidrug-resistant Staphylococcus aureus by cloned lysin derived from bacteriophage phi MR11. J Infect Dis. 196(8): 1237-47.

50. Baba T, Bae T, Schneewind O, Takeuchi F, Hiramatsu K. 2008. Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islands. J Bacteriol. Jan;190(1):300-10. Epub 2007 Oct 19.

51. Neoh HM, Cui L, Yuzawa H, Takeuchi F, Matsuo M, Hiramatsu K. 2008. Mutated Response Regulator graR Is Responsible for Phenotypic Conversion of Staphylococcus aureus from Heterogeneous Vancomycin-Intermediate Resistance to Vancomycin-Intermediate Resistance. Antimicrob Agents Chemother. Jan;52(1):45-53. Epub Oct 22.

52. Flahaut S, Vinogradov E, Kelley K, Brennan S, Hiramatsu K, Lee JC. 2008. Structural And Biological Characterization of a Capsular Polysaccharide Produced by Staphylococcus haemolyticus. J Bacteriol. 2008 Mar;190(5):1649-57.

53. Otsuka J, Kondoh Y, Amemiya T, Kitamura A, Ito T, Baba T, Cui L, Hiramatsu K, Tashiro T, Tashiro H. 2008. Development and validation of microarray-based assay for epidemiological study of MRSA. Molecular and Cellular Probes 2008 Feb;22(1):1-13.

54. Ma XX, Ito T, Kondo Y, Cho M, Yoshizawa Y, Kaneko J, Katai A, Higashiide M, Li S, Hiramatsu K. 2008. Two different PVL phage lineages predominate in Japan. J Clin Microbiol. 2008 Oct;46(10):3246-58.

55. Berglund C, Ito T, Ikeda M, Ma XX, Söderquist B, Hiramatsu K. 2008. A novel type of Staphylococcal Cassette Chromosome mec in a Methicillin-Resistant Staphylococcus aureus isolated in Sweden. Antimicrob Agents Chemother. Oct;52(10):3512-6.

56. Shimizu K, Kikuchi K, Sasaki T, Takahashi N, Ohtsuka M, Ono Y, Hiramatsu K. 2008. Smqnr, a new chromosome-encoded quinolone resistance gene in Stenotrophomonas maltophilia. Antimicrob Agents Chemother.

57. Komatsu M, Tajima Y, Ito T, Yamashiro Y, Hiramatsu K. 2008. Time-suppression test using a colorimetric probe (alamarBlue) that measures bacterial metabolic activity. Biomed Res. Jun;29(3):171-3.

58. Hoshi S, Kikuchi K, Sasaki T, Sotozono C, Kinoshita S, Hiramatsu K. 2008. Postantibiotic effects and bactericidal activities of levofloxacin and gatifloxacin at concentrations simulating those of topical ophthalmic administration against fluoroquinolone-resistant and fluoroquinolone-sensitive methicillin-resistant Staphylococcus aureus strains. Antimicrob Agents Chemother. Aug;52(8):2970-3.

59. Kishii K, Ito T, Watanabe S, Okuzumi K, Hiramatsu K. 2008. Recurrence of heterogeneous methicillin-resistant Staphylococcus aureus (MRSA) among the MRSA clinical isolates in a Japanese university hospital. J Antimicrob Chemother. Aug;62(2):324-8.

60. Camargo IL, Neoh HM, Cui L, Hiramatsu K. 2008. Serial daptomycin selection generates daptomycin-nonsusceptible Staphylococcus aureus strains with a heterogeneous vancomycin-intermediate phenotype. Antimicrob Agents Chemother. Dec;52(12):4289-99.

61. Jamaluddin TZ, Kuwahara-Arai K, Hisata K, Terasawa M, Cui L, Baba T, Sotozono C, Kinoshita S, Ito T, Hiramatsu K. 2008. Extreme genetic diversity of methicillin-resistant Staphylococcus epidermidis strains disseminated among healthy Japanese children. J Clin Microbiol. Nov;46(11):3778-83.

62. Kikuchi K, Sugita T, Makimura K, Urata K, Someya T, Sasaki T, Kamei K, Niimi M, Hiramatsu K, Uehara Y. 2008. Is Histoplasma capsulatum a native inhabitant of Japan? Microbiol Immunol. Sep;52(9):455-9.

63. Oishi K, Baba T, Nakatomi Y, Ito T, and Hiramatsu K. 2008. A Latex Agglutination Assay for Specific Detection of Panton-Valentine Leukocidin. J Microbiol Methods. Dec;75(3):411-5.

64. Watanabe Y, Neoh HM, Cui L, Hiramatsu K. 2008. Improved Antimicrobial Activity of Linezolid Against Vancomycin-Intermediate Staphylococcus aureus (VISA). Antimicrob Agents Chemother. 52:4207-4208.

65. Baba T, Kuwahara-Arai K, Uchiyama I, Takeuchi F, Ito T, Hiramatsu K. 2009. Complete genome sequence determination of a Macrococcus caseolyticus strain JSCS5402 reflecting the ancestral genome of the human pathogenic staphylococci. J Bacteriol. Feb;191(4):1180-90.

66. Cui L, Neoh HM, Shoji M, Hiramatsu K. 2009. Contribution of vraSR and graSR Point Mutations to Vancomycin Resistance in Vancomycin-intermediate Staphylococcus aureus. Antimicrob Agents Chemother. Mar;53(3):1231-4.

67. Han X, Ito T, Takeuchi F, Ma XX, Takasu M, Uehara Y, Oliveira DC, de Lencastre H, Hiramatsu K. 2009. Identification of a novel variant of staphylococcal cassette chromosome mec, type II.5, and Its truncated form by insertion of putative conjugative transposon Tn6012. Antimicrob Agents Chemother. 2009 Jun;53(6):2616-9.

68. Ohtsuka M, Kikuchi K, Shimizu K, Takahashi N, Ono Y, Sasaki T, Hiramatsu K. 2009. Emergence of quinolone-resistant Bordetella pertussis in Japan. Antimicrob Agents Chemother. 2009 Jul;53(7):3147-9.

69. Katayama Y, Murakami-Kuroda H, Cui L, Hiramatsu K. 2009. Selection of heterogeneous vancomycin-intermediate Staphylococcus aureus by imipenem. Antimicrob Agents Chemother. Aug;53(8):3190-6.

70. Watanabe S, Ito T, Sasaki T, Li S, Uchiyama I, Kishii K, Kikuchi K, Skov RL, Hiramatsu K. 2009. Genetic diversity of staphylocoagulase genes (coa): insight into the evolution of variable chromosomal virulence factors in Staphylococcus aureus. PLoS One. 2009 May 27;4(5):e5714.

71. Murakami T, Obata T, Kuwahara-Arai K, Tamura H, Hiramatsu K, Nagaoka I. 2009. Antimicrobial cathelicidin polypeptide CAP11 suppresses the production and release of septic mediators in D-galactosamine-sensitized endotoxin shock mice. Int Immunol. 2009 Aug;21(8):905-12.

72. Komatsu M, Tajima Y, Ito T, Yamashiro Y, Hiramatsu K. 2009. Use of a sensitive chemiluminescence-based assay to evaluate the metabolic suppression activity of linezolid on methicillin-resistant Staphylococcus aureus showing reduced susceptibility to vancomycin. J Microbiol Biotechnol. Jul;19(7):734-42.

73. Hongo I, Baba T, Oishi K, Morimoto Y, Ito T, Hiramatsu K. 2009. Phenol-soluble modulin alpha 3 enhances the human neutrophil lysis mediated by Panton-Valentine leukocidin. J Infect Dis. Sep 1;200(5):715-23.

74. Ohtsuka M, Kikuchi K, Shundo K, Okada K, Higashide M, Sunakawa K, Hiramatsu K. 2009. Improved selective isolation of Bordetella pertussis by use of modified cyclodextrin solid medium. J Clin Microbiol. Dec;47(12):4164-7.

75. Hiramatsu K. 2009. Resistance to Glycopeptides. Staphylococci in Human Disease 2nd Edition. Edeted by Kent B. Crossley, Kimberly K. Jefferson, Gordon L. Archer, Vance G. Fowler Jr. Wiley-Blackwell (A John Wiley & Sons, Ltd., Publication) p193-209.

76. Sasaki T, Tsubakishita S, Tanaka Y, Sakusabe A, Ohtsuka M, Hirotaki S, Kawakami T, Fukata T, Hiramatsu K. 2010. Multiplex-PCR method for species identification of coagulase-positive staphylococci. J Clin Microbiol. 2010 Mar;48(3):765-9.

77. Tsubakishita S, Kuwahara-Arai K, Baba T, Hiramatsu K. 2010. Staphylococcal cassette chromosome mec-like element in Macrococcus caseolyticus. Antimicrob Agents Chemother. Apr;54(4):1469-75.

Takashi Aoki

1. Aoki T (2003) Metabolism of parasitic protozoa. In: Progress of Medical Parasitology in Japan, Vol. 7, edited by M Otsuru et al. Chapter III. Megro Parasitological Museum, Tokyo, pp.175-191

2. Asaruddin MR, Honda G, Tsubouchi A, Nakajima-Shimada J, Aoki T, Kiuchi F (2003) Trypanocidal constituents from Michelia alba. Natural Medicines, 57, 61-63

3. Takamiya S, Yamasaki H, Hashimoto M, Taka H, Murayama K, Tagaya M, Aoki T (2003) Heterologous expression of Ascaris suum cytochrome b5 precursor protein: a histidine-tagged full-length presequence is correctly processed to transport the mature protein to the periplasm of Escherichia coli. Arch Biochem Biophys, 413, 253-261

4. Amino H, Osanai A, Miyadera H, Shinjyo N, Tomitsuka E, Taka H, Mineki R, Murayama K, Takamiya S, Aoki T, Miyoshi H, Sakamoto K, Kojima S, Kita K (2003) Isolation and characterization of the stage-specific cytochrome b small subunit (CybS) of Ascaris suum complex II from the aerobic respiratory chain of larval mitochondria. Mol Biochem Parasitol, 128, 175-186.

5. Nara T, Hirayama-Noguchi Y, Gao G, Murai E, Annoura T, Aoki T (2003) Diversity of aspartate carbamoyltransferase genes of Trypanosoma cruzi. Int J Parasitol, 33, 845-852

6. Miyahira Y, Katae M, Takeda K, Yagita H, Okumura K, Kobayashi S, Takeuchi T, Kamiyama T, Fukuchi Y, Aoki T (2003) Activation of natural killer T cells by ¦Á-galactosylceramide impairs DNA vaccine-induced protective immunity against Trypanosoma cruzi. Infect Immun, 71, 1234-1241

7. Miyahira Y, Katae M, Kobayashi S, Takeuchi T, Fukuchi Y, Abe R, Okumura K, Yagita H, Aoki T (2003) Critical contribution of CD28-CD80/CD86 costimulatory pathway to protection from Trypanosoma cruzi infection. Infect Immun, 71, 3131-3137

Miyahira Y, Akiba H, Katae M, Kubota K, Kobayashi S, Takeuchi T, Garcia-Sastre A, Fukuchi Y, Okumura K, Yagita H, Aoki T (2003)Cutting edge: a potent adjuvant effect of ligand to receptor activator of NF-kappa B gene for inducing antigen-specific CD8+ T cell response by DNA and viral vector vaccination. J Immunol, 171, 6344-6348

Hirota K, Tsubouchi A, N.-Shimada J,NaraT, Aoki T (2004)Inhibition of Trypanosoma cruzi growth in mammalian cells by nimodipine, with low cytotoxicity to host cells. Trop Med Health, 32, 181-188

Annoura T, Nara T, Makiuchi T, Hashimoto T, Aoki T (2004)The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions. J Mol Evol, 59, 1-15

Shigaku Ikeda

1. Ikeda S, Kawada J, Yaguchi H, Ogawa H: A case of unilateral, systematized linear hair follicle nevi associated with epidermal nevus-like lesions. Dermatology, 206: 172-4, 2003

2. Ikeda S, Imamura S, Hashimoto I, Morioka S, Sakuma M, Ogawa H: History of the establishment and revision of diagnostic criteria, severity index and therapeutic guidelines for pemphigus in Japan. Arch Dermatol Res, 295: S12-6, 2003

3. Tamai K, Hashimoto I, Hanada K, Ikeda S, Imamura S, Ogawa H: Japanese guidelines for diagnosis and treatment of junctional and dystrophic epidermolysis bullosa. Arch Dermatol Res, 295: S24-8, 2003

4. Umezawa Y, Ozawa A, Kawasima T, Shimizu H, Terui T, Tagami H, Ikeda S, Ogawa H, Kawada A, Tezuka T, Igarashi A, Harada S: Therapeutic guidelines for the treatment of generalized pustular psoriasis (GPP) based on a proposed classification of disease severity. Arch Dermatol Res, 295: S43-54, 2003

5. Ikeda S, Komiyama E, Ogawa H: The prognosis of pemphigus patients will be significantly improved in the future. Arch Dermatol Res, 295: S69-70, 2003

6. Muramatsu S, Kimura T, Ueki R, Tsuboi R, Ikeda S, Ogawa H: Recurrent E413K Mutation of hHb6 in a Japanese Family with Monilethrix. Dermatology, 206: 338-40, 2003

7. Aronchik I, Behne MJ, Leypoldt L, Crumrine D, Epstein Jr EH, Ikeda S, Mizoguchi M, Bench G, Pozzan T, Mauro T: Actin Reorganization is Abnormal in Hailey-Hailey Disease Keratinocytes, Due to Decreases in Cellular ATP. J Invest Dermatol, 121: 681-7, 2003.

8. Ikeda S, Mayuzumi N, Shigihara T, Epstein Jr EH, Goldsmith LA, Ogawa H: Mutations in ATP2A2 in Patients with Darier¡Çs Disease. J Invest Dermatol, 121: 475-7, 2003.

9. Wongpiyabovorn J, Suto H, Ushio H, Izuhara K, Mitsuishi K, Ikeda S, Nakao A, Okumura K, Ogawa H: Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis. J Dermatol Sci. 33: 31-40, 2003.

10. Hasegawa T, Suga Y, Mizoguchi M, Ikeda S, Ogawa H, Kubo K, Matsui H, Kagawa S, Kuroyanagi Y: Clinical tryal of allogeneic cultured dermal substitute for the treatment of intractable skin ulcers in three patients with recessive dystrophic epidermolysis bullosa. J Am Acad Dermatol, 2004, in press.

Ko Okumura


1. Akizawa, Y., C. Nishiyama, M. Hasegawa, K. Maeda, T. Nakahata, K. Okumura, C. Ra, and H. Ogawa. 2003. Regulation of human FcepsilonRI beta chain gene expression by Oct-1. Int Immunol 15:549-556.

2. Aramaki, O., N. Shirasugi, Y. Akiyama, S. Shibutani, T. Takayama, M. Shimazu, M. Kitajima, Y. Ikeda, K. Okumura, H. Yagita, and M. Niimi. 2003. CD27/CD70, CD134/CD134 ligand, and CD30/CD153 pathways are independently essential for generation of regulatory cells after intratracheal delivery of alloantigen. Transplantation 76:772-776.

3. Dan, N., T. Kanai, T. Totsuka, R. Iiyama, M. Yamazaki, T. Sawada, T. Miyata, H. Yagita, K. Okumura, and M. Watanabe. 2003. Ameliorating effect of anti-Fas ligand MAb on wasting disease in murine model of chronic colitis. Am J Physiol Gastrointest Liver Physiol 285:G754-760.

4. Funaki, T., A. Nakao, N. Ebihara, Y. Setoguchi, Y. Fukuchi, K. Okumura, C. Ra, H. Ogawa, and A. Kanai. 2003. Smad7 suppresses the inhibitory effect of TGF-beta2 on corneal endothelial cell proliferation and accelerates corneal endothelial wound closure in vitro. Cornea 22:153-159.

5. Hasegawa, M., C. Nishiyama, M. Nishiyama, Y. Akizawa, K. Mitsuishi, T. Ito, H. Kawada, S. Furukawa, C. Ra, K. Okumura, and H. Ogawa. 2003. A novel -66T/C polymorphism in Fc epsilon RI alpha-chain promoter affecting the transcription activity: possible relationship to allergic diseases. J Immunol 171:1927-1933.

6. Hasegawa, M., C. Nishiyama, M. Nishiyama, Y. Akizawa, K. Takahashi, T. Ito, S. Furukawa, C. Ra, K. Okumura, and H. Ogawa. 2003. Regulation of the human Fc epsilon RI alpha-chain distal promoter. J Immunol 170:3732-3738.

7. Hoshino, A., Y. Tanaka, H. Akiba, Y. Asakura, Y. Mita, T. Sakurai, A. Takaoka, S. Nakaike, N. Ishii, K. Sugamura, H. Yagita, and K. Okumura. 2003. Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma. Eur J Immunol 33:861-869.

8. Iwai, H., M. Abe, S. Hirose, F. Tsushima, K. Tezuka, H. Akiba, H. Yagita, K. Okumura, H. Kohsaka, N. Miyasaka, and M. Azuma. 2003. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J Immunol 171:2848-2854.

9. Kanai, T., T. Totsuka, K. Uraushihara, S. Makita, T. Nakamura, K. Koganei, T. Fukushima, H. Akiba, H. Yagita, K. Okumura, U. Machida, H. Iwai, M. Azuma, L. Chen, and M. Watanabe. 2003. Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. J Immunol 171:4156-4163.

10. Kanamaru, Y., A. Nakao, Y. Tanaka, Y. Inagaki, H. Ushio, I. Shirato, S. Horikoshi, K. Okumura, H. Ogawa, and Y. Tomino. 2003. Involvement of p300 in TGF-beta/Smad-pathway-mediated alpha2(I) collagen expression in mouse mesangial cells. Nephron Exp Nephrol 95:e36-42.

11. Kirii, Y., T. Inoue, K. Yoshino, N. Kayagaki, H. Yagita, K. Okumura, H. Shibata, Y. Yoshikawa, and K. Terao. 2003. Molecular cloning, functional characterization, and enzyme-linked immunosorbent assay of cynomolgus monkey Fas ligand. J Immunol Methods 278:201-209.

12. Maeda, K., C. Nishiyama, T. Tokura, Y. Akizawa, M. Nishiyama, H. Ogawa, K. Okumura, and C. Ra. 2003. Regulation of cell type-specific mouse Fc epsilon RI beta-chain gene expression by GATA-1 via four GATA motifs in the promoter. J Immunol 170:334-340.

13. Miura, Y., N. Misawa, Y. Kawano, H. Okada, Y. Inagaki, N. Yamamoto, M. Ito, H. Yagita, K. Okumura, H. Mizusawa, and Y. Koyanagi. 2003. Tumor necrosis factor-related apoptosis-inducing ligand induces neuronal death in a murine model of HIV central nervous system infection. Proc Natl Acad Sci U S A 100:2777-2782.

14. Miyahira, Y., H. Akiba, M. Katae, K. Kubota, S. Kobayashi, T. Takeuchi, A. Garcia-Sastre, Y. Fukuchi, K. Okumura, H. Yagita, and T. Aoki. 2003. Cutting edge: a potent adjuvant effect of ligand to receptor activator of NF-kappa B gene for inducing antigen-specific CD8+ T cell response by DNA and viral vector vaccination. J Immunol 171:6344-6348.

15. Miyahira, Y., H. Akiba, S.H. Ogawa, T. Ishi, S. Watanabe, S. Kobayashi, T. Takeuchi, T. Aoki, K. Tezuka, R. Abe, K. Okumura, H. Yagita, and N. Watanabe. 2003. Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections. Immunol Lett 89:193-199.

16. Miyahira, Y., M. Katae, S. Kobayashi, T. Takeuchi, Y. Fukuchi, R. Abe, K. Okumura, H. Yagita, and T. Aoki. 2003. Critical contribution of CD28-CD80/CD86 costimulatory pathway to protection from Trypanosoma cruzi infection. Infect Immun 71:3131-3137.

17. Miyahira, Y., M. Katae, K. Takeda, H. Yagita, K. Okumura, S. Kobayashi, T. Takeuchi, T. Kamiyama, Y. Fukuchi, and T. Aoki. 2003. Activation of natural killer T cells by alpha-galactosylceramide impairs DNA vaccine-induced protective immunity against Trypanosoma cruzi. Infect Immun 71:1234-1241.

18. Muto, T., S.D. Hsieh, Y. Sakurai, H. Yoshinaga, H. Suto, K. Okumura, and H. Ogawa. 2003. Prevalence of atopic dermatitis in Japanese adults. Br J Dermatol 148:117-121.

19. Nakayama, M., N. Harada, K. Okumura, and H. Yagita. 2003. Characterization of murine TWEAK and its receptor (Fn14) by monoclonal antibodies. Biochem Biophys Res Commun 306:819-825.

20. Nakayama, M., K. Ishidoh, Y. Kojima, N. Harada, E. Kominami, K. Okumura, and H. Yagita. 2003. Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. J Immunol 170:341-348.

21. Nishiyama, C., T. Yokota, M. Nishiyama, C. Ra, K. Okumura, and H. Ogawa. 2003. Molecular cloning of rat transcription factor YY1. Biosci Biotechnol Biochem 67:654-658.

22. Okazaki, T., S. Sakon, T. Sasazuki, H. Sakurai, T. Doi, H. Yagita, K. Okumura, and H. Nakano. 2003. Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses. Biochem Biophys Res Commun 300:807-812.

23. Sakon, S., X. Xue, M. Takekawa, T. Sasazuki, T. Okazaki, Y. Kojima, J.H. Piao, H. Yagita, K. Okumura, T. Doi, and H. Nakano. 2003. NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. Embo J 22:3898-3909.

24. Shirasugi, N., Y. Akiyama, O. Aramaki, S. Shibutani, K. Matsumoto, H. Bashuda, H. Yagita, K. Okumura, Y. Ikeda, and M. Niimi. 2003. Role of the CTLA4 pathway in hyporesponsiveness induced by intratracheal delivery of alloantigen. Transplantation 75:1636-1639.

25. Sumiyoshi, K., A. Nakao, Y. Setoguchi, K. Okumura, R. Tsuboi, and H. Ogawa. 2003. Smads regulate collagen gel contraction by human dermal fibroblasts. Br J Dermatol 149:464-470.

26. Sumiyoshi, K., A. Nakao, Y. Setoguchi, R. Tsuboi, K. Okumura, and H. Ogawa. 2003. TGF-beta/Smad signaling inhibits IFN-gamma and TNF-alpha-induced TARC (CCL17) production in HaCaT cells. J Dermatol Sci 31:53-58.

27. Tajima, A., T. Tanaka, T. Ebata, K. Takeda, A. Kawasaki, J.M. Kelly, P.K. Darcy, R.E. Vance, D.H. Raulet, K. Kinoshita, K. Okumura, M.J. Smyth, and H. Yagita. 2003. Blastocyst MHC, a putative murine homologue of HLA-G, protects TAP-deficient tumor cells from natural killer cell-mediated rejection in vivo. J Immunol 171:1715-1721.

28. Totsuka, T., T. Kanai, K. Uraushihara, R. Iiyama, M. Yamazaki, H. Akiba, H. Yagita, K. Okumura, and M. Watanabe. 2003. Therapeutic effect of anti-OX40L and anti-TNF-alpha MAbs in a murine model of chronic colitis. Am J Physiol Gastrointest Liver Physiol 284:G595-603.

29. Totsuka, T., T. Kanai, R. Iiyama, K. Uraushihara, M. Yamazaki, R. Okamoto, T. Hibi, K. Tezuka, M. Azuma, H. Akiba, H. Yagita, K. Okumura, and M. Watanabe. 2003. Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis. Gastroenterology 124:410-421.

30. Tsuji, H., S. Kawaguchi, T. Wada, S. Nagoya, M. Inobe, H. Yagita, K. Okumura, T. Yamashita, and T. Uede. 2003. Concurrent induction of T-cell activation and apoptosis of osteosarcoma cells by adenovirus-mediated B7-1/Fas chimeric gene transfer. Cancer Gene Ther 10:717-725.

31. Tsushima, F., H. Iwai, N. Otsuki, M. Abe, S. Hirose, T. Yamazaki, H. Akiba, H. Yagita, Y. Takahashi, K. Omura, K. Okumura, and M. Azuma. 2003. Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses. Eur J Immunol 33:2773-2782.

32. Uno, K., T. Inukai, N. Kayagaki, K. Goi, H. Sato, A. Nemoto, K. Takahashi, K. Kagami, N. Yamaguchi, H. Yagita, K. Okumura, T. Koyama-Okazaki, T. Suzuki, K. Sugita, and S. Nakazawa. 2003. TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells. Blood 101:3658-3667.

33. Warnnissorn, P., A. Nakao, H. Suto, H. Ushio, N. Yamaguchi, H. Yagita, K. Okumura, and H. Ogawa. 2003. Tumour necrosis factor-related apoptosis-inducing ligand expression in atopic dermatitis. Br J Dermatol 148:829-831.

34. Wongpiyabovorn, J., H. Suto, H. Ushio, K. Izuhara, K. Mitsuishi, S. Ikeda, A. Nakao, K. Okumura, and H. Ogawa. 2003. Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis. J Dermatol Sci 33:31-40.

35. Yoshimoto, T., B. Min, T. Sugimoto, N. Hayashi, Y. Ishikawa, Y. Sasaki, H. Hata, K. Takeda, K. Okumura, L. Van Kaer, W.E. Paul, and K. Nakanishi. 2003. Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice. J Exp Med 197:997-1005.

Isao Nagaoka

1. TsuTsumi-Ishii Y, Nagaoka I: Modulation of human ¦Â-defensin-2 (hBD-2) transcription in pulmonary epithelial cells by LPS-stimulated mononuclear phagocytes via pro-inflammatory cytokine production. J Immunol 170: 4226-4236, 2003

2. Ohwada A, Yoshioka Y, Iwabuchi K, Nagaoka I, Dambara T, Fukuchi Y.: VEGF regulates the proliferation of acid-exposed alveolar lining epithelial cells. Thorax 58: 328-332, 2003

3. Ohwada A, Tsutsumi-Ishii Y, Yoshioka Y, Iwabuchi K, Nagaoka I, Fukuchi Y.: Acid exposure potentiates intercellular adhesion molecule-1 and e-cadherin expression on A549 alveolar lining epithelial cells. Exp. Lung Res. 29: 389-400, 2003

4. Enomoto F, Kin R, Kataoka T, Yamazaki Y, Yokoi H, Fujimori M, Nagaoka I, Ichikawa G.: Modulation of neutrophil adhesion to vascular endothelial cells in rat experimental otitis media treated with a macrolide. Auris Nasus Larynx. 30: 247-51, 2003

5. Niyonsaba F, Hirata M, Ogawa H, Nagaoka I: Epithelial cell-derived antibacterial peptides human ¦Â-defensins and cathelicidin-multifunctional activities on mast cells. Curr Drug Targets Inflamm Allergy 2: 224-231, 2003

Sachiko Hirose

1. Kobayashi M, Kimura H, Liao J, Abe M, Hirose S, Tomino Y. Measurement of mouse urinary typeIV collagen using time-resolved fluoroimmunoassay. Anal Science, 19:205-210, 2003

2. Nakamura K, Xiu Y, Ohtsuji M, Sugita G, Abe M, Ohtsuji N, Hamano Y, Jiang Y, Takahashi N, Shirai T, Nishimura H, Hirose S. Genetic dissection of anxiety in autoimmune disease. Hum Mol Genet, 12:1079-1086, 2003

3. Fujimura S, Kuwahara K, Ezaki T, Tomita K, Hirose S, Sakaguchi N. Spontaneous increase of plasma-like cells with high GAMP expression in the extrafollicular region of lymphoid organs of autoimmune-prone mice. Autoimmunity, 20:291-301, 2003

4. Matsuoka S, Tsurui H, Abe M, Terashima K, Nakamura K, Hamano Y, Ohtsuji M, Honma N, Serizawa I, Ishii Y, Takiguchi M. Hirose S, Shirai T. A monoclonal antibody to the ¦Á2 domain of murine major histocompatibility complex class I that specifically kills activated lymphocytes and blocks liver damage in the concanavalin A hepatitis model. J Exp Med, 198:497-503, 2003

5. Iwai H, Abe M, Hirose S, Tsushima F, Tezuka K, Akiba H, Yagita H, Okumura K, Miyasaka N, Azuma M. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J Immunol, 171:2848-2854, 2003

6. Tsushima F, Iwai H, Otsuki N, Abe M, Hirose S, Yamazaki T, Akiba H, Yagita H, Takahashi Y, Omura K, Okumura K, Azuma M: Preferential contribution of B7-H1 to programmed death¡½1mediated regulation of hapten-specific allergic inflammatory responses. Eur J Immunl, 33:2773-2782, 2003

7. Li N, Nakamura K, Jiang Y, Tsurui H, Matsuoka S, Abe M, Ohtsuji M, Nishimura H, Kato K, Kawai T, Atsumi T, Koike T, Shirai T, Ueno H, Hirose S: Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. Hum Mol Genet, 13:171-179, 2004

8. Wen X, Zhang D, Kikuchi Y, Jiang Y, Nakamura K, Xiu Y, Tsurui H, Takahashi K, Abe M, Ohtsuji M, Nishimura H, Takatsu K, Shirai T, Hirose S: Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease, but increases the risk of B-cell chronic lymphocytic leukemia in a model of murine lupus. Eur J Immunol, 34:2740-2749, 2004.

9. Zhang D, Fujio K, Jiang Y, Zhao J, Tada N, Sudo K, Tsurui H, Nakamura K, Yamamoto K, Nishimura H, Shirai T, Hirose S: Dissection of the role of MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination. Proc Natl Acad Sci USA, 101:13838-13843, 2004.

10. Miyai K, Furugen Y, Matsumoto T, Iwabuchi K, Hirose S, Kinoshita K, Fujii H: Loss of heterozygosity analysis in uterine cervical adenocarcinoma. Gynecol Oncol, 94:115-20, 2004

11. Takahashi F, Tsuta K, Matsuno Y, Takahashi K, Sato K, Uekusa T, Izumi H, Nakamura K, Hirose S, Fukuchi Y. Adenocarcinoma of the thymus: mucous subtype. Human Pathol. In press.

Ken Kikuchi

1. Katahira J, Hasegawa H, Shibarta Y, Kikuchi K, Watanabe T, Totsuka K, Shimizu K: The effect of macrolides on the proliferation of hemopoietic progenitor cells. Int J Exp Clin Chemother 3: 10-18, 1990

2. Kikuchi K, Enari T, Minami S, Haruki K, Shibata Y, Hasegawa H, Katahira J, Totsuka K, Shimizu K: Postantibiotic effects and postantibiotic sub-MIC effects of benzylpenicillin on viridans streptococci isolated from infective endocarditis patients. J Antimicrob Chemother 34: 687-696, 1994

3. Kikuchi K, Enari T, Totsuka K, Shimizu K: Comparison of phenotypic characteristics, DNA-DNA hybridization results,and results with a commercial rapid biochemical and enzymatic reaction system for identification of viridans group streptococci. J Clin Microbiol 33: 1215-1222, 1995

4. Kikuchi K, Totsuka K, Shimizu K, Ishii T, Yoshida T, Orikasa Y: Effects of combination of benzylpenicillin and fosfomycin on penicillin- resistant Streptococcus pneumoniae. Microb Drug Resist 1: 185-189, 1995

5. Sadownik A, Deng G, Janout V, Regen SL, Bernard EM, Kikuchi K, Armstrong D: Rapid construction of a squalamine mimic. J Am Chem Soc 117: 6138-6139, 1995

6. Kikuchi K*, De Lencastre H, Eagan J, Boone N, Bernard N, Armstrong D, Tomasz A: Double inhibition zone phenomenon in methicillin-resistant Staphylococcus aureus (MRSA). Clin Infect Dis 23: 894, 1996

7. Kikuchi K*, Bernard EM, Sadownik A, Regen SL, Armstrong D: Antimicrobial activities of squalamine mimics. Antimicrob Agents Chemother 41: 1433-1438, 1997

8. Ochiai K, Kikuchi K, Gukushima K, Kurita-Ochiai T: Co-aggregation as a virulent factor of Streptococcus sanguis isolated from infective endocarditis. J Oral Science 41: 117-122, 1999

9. Totsuka K, Shiseki M, Kikuchi K, Matsui Y: Combined effects of vancomycin and imipenem against methicillin-resistant Staphylococcus aureus (MRSA) in vitro and in vivo. J Antimicrob Chemother 44: 455-460, 1999

10. Aires de Sousa M, De Lencastre H, Santos-Sanches I, Kikuchi K, Totsuka K, Tomasz A: Similarity of antibiotic resistance patterns and molecular typing properties of methicillin-resistant Staphylococcus aureus isolates widely spread in hospitals in New York City and in a hospital in Tokyo, Japan. Microb Drug Resist 6: 221-226, 2000

11. Shiseki M, Hidai H, Kikuchi K, Totsuka K: Genotypic similarities among the methicillin-resistant Staphylococcus aureus isolates recovered from stools, the respiratory tract and other sites in 20 patients. J Hosp Infect 45: 244-248, 2000

12. Chung M, De Lencastre H, Matthews P, Tomasz A, Adamsson I, Aires de Sousa M, Camou T, Cocuzza C,Corso A, Couto I, Dominguez A, Gniadkowski M, Goering R, Gomes A, Kikuchi K, Marchese A, Mato R, Melter O, Oliveira D, Palacio R, Sa-Leao R, Sanches IS, Song JH, Tassios PT, Villari P: Molecular typing of methicilin-resistant Staphylococcus aureus by pulsed-field gel electrophoresis: comparison of results obtained in a multilaboratory effort using identical protocols and MRSA strains. Microb Drug Resist 6: 189-198, 2000

13. Sanches IS, Mato R, De Lencastre H, Tomasz A, Nunes S, Alves CR, Miragaia M, Carrico J, Couto I, Bonfilm I, Aires de Sousa M, Oliveira D, Gomes A, Vaz M, Fernandes S, Verde SC, Avila S, Antunes F, Sa-Laeao R, Almeida J, Melter O, Chung M, Jia F, Kikuchi K, Konkoly-Thege M, Kristinsson KG, Linares J, Rossi A, Savov EZ,Schindler J, Solorzano-Santos F, Totsuka K, Venditti M, Villari P, Westh H, Wu JS, Zanella RC: Patterns of multidrug resistance among methicillin-resistant hospital isolates of coagulase-positive and coagulase-negative staphylococci collected in the international multicenter study RESIST in 1997 and 1998. Microb Drug Resist 6: 199-211, 2000

14. Uehara Y, Kikuchi K, Nakamura T, Nakama H, Agematsu K, Kawakami Y, Maruchi N, Totsuka K: Inhibition of methicillin-resistant Staphylococcus aureus colonization of oral cavities in newborns by viridans group streptococci. Clin Infect Dis 32: 1399-1407, 2001

15. Uehara Y, Kikuchi K, Nakamura T, Nakama H, Agematsu K, Kawakami Y, Maruchi N, Totsuka K: H2O2 produced by viridans group streptococci may contribute to inhibition of methicillin-resistant Staphylococcus aureus colonization of oral cavity of newborns. Clin Infect Dis 32: 1408-1413, 2001

16. Kawabata S, Kunitomo E, Terao Y, Nakagawa I, Kikuchi K, Totsuka K, Hamada S: Systemic and mucosal immunizations with fibronectin-binding protein FBP54 induce protective immune response against Streptococcus pyogenes challenge in mice. Infect Immun 69: 924-930, 2001

17. Takeda N, Kikuchi K. Asano R, Harada T, Totsuka K, Sumiyoshi T, Uchiyama T, Hosoda S: Recurrent septicemia caused by Streptococcus canis after a dog bite. Scand J Infect Dis 33: 927-928, 2001

18. Matsumoto N, Shiraga H, Takahashi K, Kikuchi K, Ito K: Successful treatment of Aspergillus peritonitis in a peritoneal dialysis patient. Pediatr Nephrol 17: 243-245, 2002

19. Murakami J, Kawabarta S, Terao Y, Kikuchi K, Totsuka K, Tamaru A, Katsukawa C, Moriya K, Nakagawa I, Morisaki I, Hamada S: Distribution of emm genotype and superantigen genes of Streptococcus pyogenes isolated in Japan, 1994-9. Epidemiol Infect 128 397-404, 2002

20. Matsuda Y, Kato H, Yamada R, Okano H, Ohta H, Imanishi K, Kikuchi K, Totsuka K, Uchiyama T: Early diagnosis of toxic shock syndrome by detection of T-cell-receptor V¦Â2-positive T cells. Emerg Infect Dis 9: 387-389, 2003

21. Miyoshi-Akiyama T, Zhao J, Kato H, Kikuchi K, Totsuka K, Kataoka Y, Katsumi M. Uchiyama T: Streptococcus dysgalactiae-derived mitogen (SDM), a novel bacterial superantigen: characterization of its biological activity and predicted tertiary structure. Mol Microbiol 47:1589-1599, 2003

22. Kamei K, Sano A, Kikuchi K, Makimura K, Niimi M, Suzuki K, Uehara Y, Okabe N, Nishimura K, Miyaji M: The trend of imported mycoses in Japan. J Infect Chemother 9: 16-20, 2003

23. Yamaura H, Araki K, Kikuchi K, Itoda I, Totsuka K, Kobayakawa T: Evaluation of dot-ELISA for serological diagnosis of amebiasis. J Infect Chemother 9: 25-29, 2003

24. Miyoshi-Akiyama T, Zhao J, Kikuchi K, Kato H, Suzuki R, Endoh M, Uchiyama T: Quantitative and qualitative comparison of virulence traits, including murine lethality, among different M types of group A streptococci. J Infect Dis 187: 1876-1887, 2003

25. Kikuchi K*, Takahashi N, Piao C, Totsuka K, Nishida H, Uchiyama T: Molecular epidemiology of methicillin-resistant Staphylococcus aureus strains causing neonatal toxic syndrome-like exanthematous disease (NTED)¡¡in neonatal and perinatal wards. J Clin Microbiol 41: 3001-3006, 2003

26. Mudany MA, Kikuchi K*, Totsuka K, Uchiyama T: Evaluation of a new serotyping kit for Streptococcus pneumoniae. J Med Microbiol 52: 975-980, 2003

27. Kikuchi K*, Karasawa T. Piao C, Itoda I, Hidai H, Yamaura H, Totsuka K, Morikawa T, Takayama M: Molecular confirmation of transmission route of Staphylococcus intermedius in mastoid cavity infection from dog saliva. J Infect Chemother 10: 46-48, 2004

28. Ikeda Y, Ohara-Memoto Y, Kimura S, Ishibashi K, Kikuchi K: PCR-based identification of Staphylococcus epidermidis targeting gseA encoding the glutamic acid-specific protease. Can J Microbiol 50: 493-498, 2004

29. Sugita T, Kikuchi K, Makimura K, Urata K, Someya T, Kamei K, Nimi M, Uehara Y: Trichosporon species isolated from guano samples obtained from bat-inhibited caves in Japan. Appl Environm Microbiol 71: 7626-7629, 2005

30. Shimokawa O, Niimi M, Kikuchi K, Saito M, Kajiwara H, Yoshida S: Relationship between MIC and minimum sterol 14¦Á-demethylation-inhibitory concentration as a factor in evaluating activities of azoles against various fungal species. J Clin Microbiol 43: 5547-5549, 2005

31. Piao C, Karasawa T, Totsuka K, Uchiyama T, Kikuchi K*: Prospective surveillance of community-onset and healthcare-associated methicillin-resistant Staphylococcus aureus isolated from a university-affiliated hospital in Japan. Microbiol Immunol 49: 959-970, 2005

32. Aikawa N, Fujishima S, Endo S, Sekine I, Kogawa K, Yamamoto Y, Kushimoto S, Yukioka H, Kato N, Totsuka K, Kikuchi K, Ikeda T, Ikeda K, Harada K, Satomura S: Multicenter prospective study of procalcitonin as an indicator of sepsis. J Infect Chemother 11: 152-159, 2005

33. Durand G, Bes M, Meugnier H, Enright MC, Forey F, Liassine N, Wenger A, Kikuchi K, Lina G, Vandenesch F, Etienne J: Detection of new methicillin-resistant Staphylococcus aureus clones containing the toxic shock syndrome toxin 1 gene responsible for hospital- and community-acquired infections in France. J Clin Microbiol 44: 847-853, 2006.

34. Haruta I, Hashimoto E, Kato Y, Kikuchi K, Kato H, Yagi J, Uchiyama T, Kobayashi M, Shiratori K: Lipoteichoic acid may affect the pathogenesis of bile duct damage in primary biliary cirrhosis. Autoimmunity 39:129-135, 2006.

35. Uehara Y, Agematsu K, Kikuchi K, Matsuzaki S. Imai S, Takamoto M, Sugane K, Sugiura T, Konishi Y, Yoshino N, Takeuchi S, Seo H, Kuramoto S, Sugai M: Secretory IgA, peroxidase, and catalase-mediated microbicidal activity during H2O2 catabolism in viridans streptococci-pathogen co-aggregation. J Infect Dis 196: 98-107, 2006.

36. Shin N, Sugawara Y, Tsukada K, Tamura S, Akamatsu N, Okugawa S, Koike K, Kikuchi K, Makuuchi M. Successful treatment of disseminated Nocardia farcinica infection in a living-donor liver transplantation recipient. Transplant Infect Dis 8: 222-225, 2006

37. Sasaki T, Kikuchi K, Tanaka Y, Takahashi N, Kamata S, Hiramatsu K. Methicillin-resistant Staphylococcus pseudintermedius in a veterinary teaching hospital. J Clin Microbiol 45: 1118-1125, 2007

38. Tomita T, Ohara-Nemoto Y, Moriyama H, Ozawa A, Takeda Y, Kikuchi K. A novel in vitro pharmacokinetic model to simulate serum drug concentration-time profiles. Microbiol Immunol 51: 567-575, 2007

39. Sasaki T, Kikuchi K, Tanaka Y, Takahashi N, Kamata S, Hiramatsu K. Reclassification of phenotypically-identified Staphylococcus intermedius strains. J Clin Microbiol 45: 2770-2778, 2007

40. Haruta I, Kikuchi K, Hashimoto E, Kato H, Hirota K, Kobayashi M, Miyake Y, Uchiyama T, Yagi J, Shiratori K. A possible role of histone-like DNA-binding protein of Streptococcus intermedius in the pathogenesis of bile duct damage in primary biliary cirrhosis. Clin Immunol 127: 245-251, 2008.

41. Endo S, Aikawa N, Fujishima Fujishima S, Sekine I, Kogawa K, Yamamoto Y, Kushimoto S, Yukioka H, Kato N, Totsuka K, Kikuchi K, Ikeda T, Ikeda K, Yamada H, Harada K, Satomura S: Usefulness of procalcitonin serum level for the discrimination of severe sepsis from sepsis: a multicenter prospective study. J Infect Chemother 14: 244-249, 2008

42. Hoshi S, Kikuchi K, Sasaki T, Sotozono C, Kinoshita S, Hiramatsu K. Postantibiotic effects and bactericidal activities of levofloxacin and gatifloxacin at concentrations simulating those of topical ophthalmic administration against fluoroquinolone-resistant and fluoroquinolone-sensitive methicillin-resistant Staphylococcus aureus strains. Antimicrob Agents Chemother 52: 2970-2973, 2008 (doi:10.1128/AAC.01466-07)

43. Kikuchi K, Sugita T, Makimura K, Urata K, Someya T, Sasaki T, Kamei K, Niimi M, Hiramatsu K, Uehara Y. Is Histoplasma capsulatum a native inhabitant of Japan? Microbiol Immunol 52: 2008 in press.

44. Shimizu K, Kikuchi K, Sasaki T, Takahashi N, Ohtsuka M, Ono Y, Hiramatsu K. Smqnr, a new chromosome-encoded quinolone resistance gene in Stenotrophomonas maltophilia. Antimicrob Agents Chemother 52: 2008 e-published.

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