http://www.infection-control.jp/english/ en Copyright 2008 Wed, 05 Mar 2008 11:09:09 +0900 http://www.sixapart.com/movabletype/?v=3.2-ja-2 http://blogs.law.harvard.edu/tech/rss http://sciencewatch.com/ana/st/mrsa/08marSTmrsaHira/]]> http://www.infection-control.jp/english/010news/interview_released_on_thomson.html http://www.infection-control.jp/english/010news/interview_released_on_thomson.html 010)News Wed, 05 Mar 2008 11:09:09 +0900 One of the senior students and enthusiastic member of Infection Control Science has been passed the examination and became the Infection Control Microbiological Technologist (ICMT). http://www.infection-control.jp/english/010news/kozue_kishi_has_been_passed_ic.html http://www.infection-control.jp/english/010news/kozue_kishi_has_been_passed_ic.html 010)News Fri, 29 Feb 2008 17:44:25 +0900 April 2007 to March 2008 ------------------------------------------------------------------------------------ 07/07/03 Michael Gilmore Harvard Medical School Department of Ophthalmology Vancomycin Resistant Enterococci: How commensal bacteria become hospital pathogens. ------------------------------------------------------------------------------------ 07/11/28 Christof von Eiff University Hospital of Muenster Small Colony Variant ------------------------------------------------------------------------------------ 07/12/03 Henry Chambers San Francisco General Hospital Community MRSA ------------------------------------------------------------------------------------ 08/02/08 Jae-Hoon Song Samsung Medical Center April 2005 to March 2006 ------------------------------------------------------------------------------------ 06/02/03-06 Dawn Hill North Bristol NHS Trust Southmead Hospital Practical infection control ------------------------------------------------------------------------------------ 06/01/16-19 Eric Taylor Inverclyde Royal Hospital - Argyll & Clyde Acute Hospitals NHS Trust Greenock 1 Factors influencing the incidence of Surgical Site Infection (SSI) (1/16) 2 Patient preparation (1/16) 3 Antibiotic prophylaxis (1/17) 4 Rituals in the operating theatre (1/17) 5 Does minimally invasive surgery influence the incidence of SSI? (1/18) 6 Surgical wound care (1/18) 7 Audit of postoperative infection (1/19) 8 Post-discharge surveillance (1/19) ------------------------------------------------------------------------------------ 05/10/03-06 Tyrone Pitt Laboratory of HealthCare Associated Infection 1 Structure and functions of reference microbiological laboratories in UK (10/3) 2 Interaction of clinical and reference laboratories to improve patient management(10/3) 3 Quality control assurance in microbiological laboratories(10/4) 4 Identification and typing in the clinical and reference laboratory(10/4) 5 Introduction to bacterial typing(10/5) 6 Phenotypic typing methods(10/5) 7 Molecular typing I(10/6) 8 Molecular typing II(10/6) ------------------------------------------------------------------------------------ 05/05/09-12 Ed Smyth Director of Northern Ireland Healthcare-Associate Infection Surveillance Centre (HISC) Introduction to Surveillance and HISC (5/9) Overview of Surveillance of HCAI (5/9) Setting-UP Surveillance (5/10) Automated Data Entry (5/10) SSI Surveillance (5/11) Data Feedback (5/11) Surveillance in the ICU (5/12) Cost-effectiveness of Surveillance for SSI (5/12) April 2004 to March 2005 ------------------------------------------------------------------------------------ 05/03/14-17 Hilary Humphreys RCSI Education & Research Centre Theatres construction and commissioning MRSA control Infections in ICUs Medical device associated infections ------------------------------------------------------------------------------------ 05/01/24-27 Peter Hawkey West Midlands Public Health Laboratory, Health Protection Agency, Birmingham Molecular typing methods Control of tuberculosis New use in identifying and controlling outbreaks ------------------------------------------------------------------------------------ 04/12/13-16 Michael Emmerson President of Hospital Infection Society, Queens Medical Centre Perspective of Infection control Repeated prevalence surveillance in hospitals ------------------------------------------------------------------------------------ 04/11/15-18 Robert Spencer Chair of Hospital Infection Society, Health Protection Agency, Bristol Bioterrorism Laboratory diagnostic needs for infection Control Prevention of Central Venous catheter infections and new CVC devices ------------------------------------------------------------------------------------ 04/11/08-11 Richard Slack Queens Medical Centre Outbreak recognition and control in the community Legionnaires disease and air-borne pathogens ------------------------------------------------------------------------------------ 04/10/18-21 Adam Fraise Hospital Infection Research Laboratory Birmingham, City Hospital, Birmingham Disinfection and sterilization Endoscopy unit Antibiotic policies and prescription control Decontamination ------------------------------------------------------------------------------------ 04/07/05-08 Peter Hoffman Laboratory of Health Care Associated Infection, Health Protection Agency, London Hospital Environment and laundry Theatre ventilation Isolation and ventilation Decontamination of medical equipment Prions (Transmissible spongiform encephalopathy) Sterile Services Department (Functions of SSD)]]> http://www.infection-control.jp/english/030dics_course/international_lecture_series.html http://www.infection-control.jp/english/030dics_course/international_lecture_series.html 030)DICS Course Fri, 29 Feb 2008 13:15:00 +0900 Watch Nobich! ¢÷ Juntendo University Infection Control Team and Nurses have been developed the pendant styled watch called "Nobich (R) I.C." that is ideal for hospital infection control. Unlike the watches with the wrist band, Nobich does not disturb the hand wash. The clip and the watch are connected with a reel that can be extended to 55 cm. This new idea solved the problems of the classical nurse watches. You may bring the watch to be the eye level. History of Nobich Nobich, sounds "Nobiru", extension in Japanese or stretch in English has been developed by two nurses, Megumi Ikeda (ICN, Student of Infection Control Science) and Noriko Terunuma (nurse manager of Juntendo University Hospital). The first model of Nobich was produced as limitation edition. However, the good reputation of Nobich was soon to be know, and the stock were all sold out. Since then, Nobich has been one of the popular products of Juntendo University Hospital, and it is often ordered from all over the country. Today, Nobich is becoming to be know by medical institutions in abroad. The order mails are arriving constantly. How to Order Nobich Please send E-mail to Megumi Ikeda for ordering or questions about Nobich. There are two types, one is with Juntendo logo and other is hand wash logo, and the price is 4,900JPY. You may use your original logo for over 200 order. Order Nobich to: ¢÷¢÷]]> http://www.infection-control.jp/english/010news/pendant_watch_for_hospital_wor_1.html http://www.infection-control.jp/english/010news/pendant_watch_for_hospital_wor_1.html 010)News Fri, 29 Feb 2008 12:17:42 +0900 ICD Short Training Course is a six months training program. The DICS four year graduate course has been established in 2004 and has accepted 26 students (as of February, 2008) with varieties of the academic or occupational backgrounds. However, the four-year course is difficult to attend for the clinicians who are full time on duty at the hospital. The ICD short training course has been designed for such medical doctors or nurses to master the essential knowledge and practical techniques in six months. Aim: With an intensive lecture series of 2 weeks and 5 months clinical training, ICD short training course provides medical personnels with a minimum requirement for infection control practice. Admission requirements: Physicians or nurses who are involved in hospital infection control. Fluency in Japanese is required. Goal: Be able to plan a programme to prevent hospital infection control. Be able to educate hospital staffs about infection control as a member of hospital infection control team. Be able to advise hospital staffs about the proper use of antibiotics. Term: 6 months (extendable by attendees' request) Requirements and grading: - Attending the intensive lecture course is required to be enroled in the clinical training course. - In the clinical training course, infection control training, Infectious disease consultation, clinical microbiology laboratory training are compulsory. Epidemiologic analysis, general clinical laboratory techniques, use of antibiotics are selective subjects. Attendees are expected to submit reports. The reports is graded by instructors. Titles: A certificate is issued by Jutendo University proving that the applicant has finished the ICD short traning couruse. Curriculum: Intensive lecture course is held in the first two weeks, and attendees must pass the examination of all the subjects taught in the course before the enrolement in the clinical traning course. Contents of the lecture course are: Infection control (12h), Infectious diseases and epidemiology (4h), Infection diagnosis (9h), Clinical microbiology (5h), Infectious disease treatment (10h). Clinical Training: Infection control training, Infectious disease consultation, and clinical laboratory training are held in the following 5 months. 1) Infection control training: Designing an infection control program that will be used in the attendee's institution (for examle: Creating an infection control manual, designing a surveillance of post-operative infection, designing a free influenza vaccination plan for the staffs and a way of evaluation of its effectiveness, designing a low-pressure room for the prevention of the airborne infection and its management etc). 2) Epidemiologic analysis: Design and perform his/her own project that is correlated with those projects being performed by Juntendo Infection Control Team on such topics as the hospital outbreak, prospective surveillance, and typing of clinical isolates. Presentation of the results in the Annual meetings of Infectious Disease Society or of Japanes Society for Environmental Infections. 3) Infectious disease consultation Together with infectious disease consultants, attendees visit patients by their doctors' requests. Make the treatment plan with the patients' doctors. Attendees perform Gram staining and Acid-fast staining by themselves. Submit summary at the end of the treatment or by lecturer's order. The format is follow as case report format for Internal Medicine Specialists. 15 reports are expected. 4) Clinical microbiology: A quick typing training composed of Gram staining (6h), Acid-fast staining (2h), and parasite staining (ex. malaria, 2h), is the prerequisite before the consultation training. Attendees can take a research course by chosing a microbe isolated in the clinical laboratory and analyze its characteristics (examples: Drug resistance pattern of an MRSA isolated from the skin of a patient. Isolation of mycoplasma from the nasal cavity of a patient with acute upper respiratory tract infection. Distribution of Lactococcus from urinal tract infection). Attendees may submit a report together with that of 'Epidemiologic analysis' study. 5) Proper use of antibiotics: Design a practical plan for the attendee's institution. (examples: Perform the surveillance on the selection of antibiotics to know how often the opinions of pharmaceutical companies and hospital pharmacists are involved in the decision. List all the problems related to use of antibiotics and find the solution. Design the report system of carbapenem use at certain wards.)]]> http://www.infection-control.jp/english/035icd_course/010contents_1.html http://www.infection-control.jp/english/035icd_course/010contents_1.html 035)ICD Course Tue, 19 Feb 2008 17:31:13 +0900 http://www.cdc.gov/ ¢£National Center for Infectious Diseases http://www.cdc.gov/ncidod/ ¢£National Center for Biotechnology Information http://www.ncbi.nlm.nih.gov/ Enrezt-the GenBank Sequence Database BLAST-NCBI's sequence similarity search tool designed to support analysis of nucleotide and protein databases. ¢£American Society for Microbiology http://www.asm.org/ ¢£Infectious Disease Surveillance Center http://www.nih.go.jp/niid/index.html ¢£U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Foodborne Pathogenic Microorganisms and Natural Toxins Handbook http://vm.cfsan.fda.gov/~MOW/intro.html ¢£Scottish MRSA Reference Laboratory http://www.show.scot.nhs.uk/smrsarl/ The web site for the Scottish MRSA Reference is now "live"! ¢£Asian-Pacific Research Foundation for Infectious Diseases http://www.ansorp.org/ ARFID is a core infrastructure for research on infectious diseases and antimicrobial agents in the Asian-Pacific region.
]]> http://www.infection-control.jp/english/070link/link_1.html http://www.infection-control.jp/english/070link/link_1.html 070)Link Wed, 31 May 2006 15:33:03 +0900 ºîÀ®Ãæ http://www.infection-control.jp/english/060topics/010from_the_latest_paper.html http://www.infection-control.jp/english/060topics/010from_the_latest_paper.html 060)Topics Wed, 31 May 2006 15:32:39 +0900 Faculty Name Title Affiliation Information Eiki Kominami Professor Infection Control Science Department of Hed Installation Keiichi Hiramatsu Professor Infection Control Science Professor of Bacteriology¢÷
Leader of COE Teruyo Ito Associate Professor Infection Control Science Associate Professor of Department of Bacteriology Longzhu Cui Lecturer Infection Control Science Lecturer of Department of Bacteriology Tadashi Baba Lecturer Infection Control Science Lecturer of Department of Bacteriology Satoshi Hori Lecturer Infection Control Science ICD (DipHIC) Fumihiko Takeuchi Lecturer Infection Control Science Bioinformatics Kentaro Iwata Lecturer Infection Control Science ICD
Kameda Medical Center Mayumi Aminaka Assistant Infection Control Science ICN         Project Members¡ÊEducation Research¡Ë Name Title Department Notes Takashi Aoki Professor Department of Molecular and Cellular Parasitology Covering lecture series Ko Okumura Professor Department of Immunology Covering lecture series Isao Nagaoka Professor Department of Host Defense and Biochemical Research Covering lecture series Eiji Marui Professor Department of Public Health Covering lecture series Yuichiro Yamashiro Professor Department of Pediatrics and Adolescent Medicine Suminobu Ito Professor Department of Clinical Pharmacology Takeshi Miyano Professor Department of Pediatric General and Urogenital Surgery Director Akira Yanai Professor Department of Plastic and Reconstructive Surgery Director Fujime Makoto Professor Department of Urology Amano Atsushi Professor Department of Cardiovascular Surgery Seiji Kawasaki Professor Department of Hepato-Biliary-Pancreatic Surgery Masahiko Tsurumaru Professor Department of Esophageal & Gastroenterological Surgery Hisashi Kurosawa Professor Department of Orthopaedic Surgery Yoshinosuke Fukuchi Professor Department of Internal Medicine Director of ICD Sachiko Hirose Associate Professor Department of Molecular Pathogenesis Covering lecture series Ikeda Shigaku Professor Department of Dermatology and Allergology Hiroshi Isonuma Lecturer Department of General Medicine Jun Igari Professor Department of Clinical Pathology Director of Juntendo Urayasu Hospital         Adviser Name Title Institution Notes Kani Kobayashi Chancellor Kanto Medical Center NTT EC Satoshi Kimura Head of the Center International Medical Center of Japan
AIDS Clinical Center  
]]> http://www.infection-control.jp/english/020introduction/faculty.html http://www.infection-control.jp/english/020introduction/faculty.html 020)Introduction Wed, 19 Apr 2006 12:05:13 +0900 Admission Guidelines for 2008. 21st Century Center of Excellence Program Infection Control Science invite applications from students who are qualify and enthusiastic for hospital infection control. Confirm the department aims on this website, and contact by message form. ---- Entrance examination Early schedule September 20, 2007 Application deadline August 31, 2007 Late schedule January 18, 2008 Application deadline December 21, 2007 --- Spread of nosocomial infection, mainly by antibiotic resistant strains, are giving great impact on modern medical treatment. Controlling nosocomial infection is necessary, and specialists are strongly wanted. The practical training is based on dipHIC (diploma of Hospital Infection Control) in UK, while the basic science training is original. Since 2008, Infection Control Doctor course at Mayo Clinic (USA) become the partner with our team to power up the infectious disease education. Laboratory experiment with world top level genome science and immunology engineering also support students to become infection control scientists with the global standard. Students will receive the degree of "Doctor of Infection Control Science: DICS", at their graduation. http://www.infection-control.jp/english/010news/news1.html http://www.infection-control.jp/english/010news/news1.html 010)News Fri, 14 Apr 2006 11:55:44 +0900 http://www.ansorp.org/]]> http://www.infection-control.jp/english/100juntendo_university/link.html http://www.infection-control.jp/english/100juntendo_university/link.html 100)Juntendo University Wed, 29 Mar 2006 13:49:33 +0900 ºîÀ®Ãæ http://www.infection-control.jp/english/050activities/010press_releases.html http://www.infection-control.jp/english/050activities/010press_releases.html 050)Activities Wed, 29 Mar 2006 11:35:10 +0900 Publications of the COE faculty. Keiichi Hiramatsu 1. Ito, T., Okuma, K., Ma, X.X., Yuzawa, H., and Hiramatsu, K. 2003. Insights on Antibiotic Resistance of Staphylococcus aureus from its Whole Genome: Genomic Island SCC. Drug Res. Updates. 6: 41-52. 2. Cui, L., Ma, X., Sato, K., Okuma, K., Tenover, F. C., Mamizuka, E. M., Gemmell, C. G., Kim, M-N., Ploy, M-C., Solh, N. E., Ferraz, V., and Hiramatsu, K. 2003. Cell Wall Thickening Is a Common Feature of Vancomycin Resistance in Staphylococcus aureus. J. Clin. Microbiol.41:5-14. 3. Yoshida, R., Kuwahara-Arai, Baba, T., Cui, L., Richardson, J. F., and K. Hiramatsu. 2003. Physiological and molecular analysis of a mecA-negative Staphylococcus aureus clinical strain that expresses heterogeneous methicillin resistance J Antimicrob Chemother 51:247-255. 4. Katayama, Y., Takeuchi, F., Ito, T., Ma1, X. X., Ui-Mizutani , Y., Kobayashi, I., and Hiramatsu, K. 2003. Identification in a methicillin-susceptible Staphylococcus hominis of an active primordial mobile genetic element for the staphylococcal cassette chromosome mec (SCCmec) of methicillin-resistant Staphylococcus aureus. J. Bacteriol. 185:2711-2722. 5. Isnansetyo, A., Cui, L., Hiramatsu, K., and Kamei, Y. 2003. Antibacterial activity of 2,4-diacetylphloroglucinol (DAPG) produced by Pseudomonas sp. AMSN isolated from a marine alga, against vancomycin-resistant Staphylococcus aureus (VRSA). Int J Antimicrob Agents¡¡22:545-7. 6. Kuroda, M., Kuroda, H., Oshima, T., Takeuchi, F., Mori, H., and Hiramatsu, K. 2003. Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus. Molecular Microbiol. 49: 807-821. 7. Cui, L., and K. Hiramatsu. 2004. Vancomycin-resistant Staphylococcus aureus. in ed, by Franz-Josef Schmitz and Dr. Ad C. Fluit. MRSA. Horizon Scientific Press. 8. Kuroda, M., and K. Hiramatsu. 2004. Genome sequencing and annotation: an overview in Johnson, A., and Woodford, N., ed., Genomics, Proteomics and Clinical Bacteriology. Humana Press. 9. Baba, T.,Takeuchi, F., Kuroda, M., Yuzawa, H., Ito, T., and Hiramatsu, K. 2004. The Genome of Staphylococcus aureus. pp In Al¡ÇAladeen, D., and Hiramatsu, K (ed). The Staphylococcus aureus: Molecular and Clinical Aspects. Eliis Harwood, London, UK. 10. Hiramatsu, K. 2004. Elucidation of the mechanism of antibiotic resistance acquisition of methicillin-resistant Staphylococcus aureus (MRSA) and determination of its whole genome nucleotide sequence. Jap Med Assoc 47(4): 153?159. 11. Hiramatsu, K., Kuroda, M., Baba, T., and K. Okuma. 2004. Application of Genomic Information to the Diagnosis, Management and Control of Bacterial Infections: The Staphylococcus aureus model In ed.by D. Persing, et al. Diagnostic Molecular Microbiology 2nd Ed, pp407-418, ASM Press. Takashi Aoki 1. Aoki T (2003) Metabolism of parasitic protozoa. In: Progress of Medical Parasitology in Japan, Vol. 7, edited by M Otsuru et al. Chapter III. Megro Parasitological Museum, Tokyo, pp.175-191 2. Asaruddin MR, Honda G, Tsubouchi A, Nakajima-Shimada J, Aoki T, Kiuchi F (2003) Trypanocidal constituents from Michelia alba. Natural Medicines, 57, 61-63 3. Takamiya S, Yamasaki H, Hashimoto M, Taka H, Murayama K, Tagaya M, Aoki T (2003) Heterologous expression of Ascaris suum cytochrome b5 precursor protein: a histidine-tagged full-length presequence is correctly processed to transport the mature protein to the periplasm of Escherichia coli. Arch Biochem Biophys, 413, 253-261 4. Amino H, Osanai A, Miyadera H, Shinjyo N, Tomitsuka E, Taka H, Mineki R, Murayama K, Takamiya S, Aoki T, Miyoshi H, Sakamoto K, Kojima S, Kita K (2003) Isolation and characterization of the stage-specific cytochrome b small subunit (CybS) of Ascaris suum complex II from the aerobic respiratory chain of larval mitochondria. Mol Biochem Parasitol, 128, 175-186. 5. Nara T, Hirayama-Noguchi Y, Gao G, Murai E, Annoura T, Aoki T (2003) Diversity of aspartate carbamoyltransferase genes of Trypanosoma cruzi. Int J Parasitol, 33, 845-852 6. Miyahira Y, Katae M, Takeda K, Yagita H, Okumura K, Kobayashi S, Takeuchi T, Kamiyama T, Fukuchi Y, Aoki T (2003) Activation of natural killer T cells by ¦Á-galactosylceramide impairs DNA vaccine-induced protective immunity against Trypanosoma cruzi. Infect Immun, 71, 1234-1241 7. Miyahira Y, Katae M, Kobayashi S, Takeuchi T, Fukuchi Y, Abe R, Okumura K, Yagita H, Aoki T (2003) Critical contribution of CD28-CD80/CD86 costimulatory pathway to protection from Trypanosoma cruzi infection. Infect Immun, 71, 3131-3137 Miyahira Y, Akiba H, Katae M, Kubota K, Kobayashi S, Takeuchi T, Garcia-Sastre A, Fukuchi Y, Okumura K, Yagita H, Aoki T (2003)Cutting edge: a potent adjuvant effect of ligand to receptor activator of NF-kappa B gene for inducing antigen-specific CD8+ T cell response by DNA and viral vector vaccination. J Immunol, 171, 6344-6348 Hirota K, Tsubouchi A, N.-Shimada J,NaraT, Aoki T (2004)Inhibition of Trypanosoma cruzi growth in mammalian cells by nimodipine, with low cytotoxicity to host cells. Trop Med Health, 32, 181-188 Annoura T, Nara T, Makiuchi T, Hashimoto T, Aoki T (2004)The origin of dihydroorotate dehydrogenase genes of kinetoplastids, with special reference to their biological significance and adaptation to anaerobic, parasitic conditions. J Mol Evol, 59, 1-15 Shigaku Ikeda 1. Ikeda S, Kawada J, Yaguchi H, Ogawa H: A case of unilateral, systematized linear hair follicle nevi associated with epidermal nevus-like lesions. Dermatology, 206: 172-4, 2003 2. Ikeda S, Imamura S, Hashimoto I, Morioka S, Sakuma M, Ogawa H: History of the establishment and revision of diagnostic criteria, severity index and therapeutic guidelines for pemphigus in Japan. Arch Dermatol Res, 295: S12-6, 2003 3. Tamai K, Hashimoto I, Hanada K, Ikeda S, Imamura S, Ogawa H: Japanese guidelines for diagnosis and treatment of junctional and dystrophic epidermolysis bullosa. Arch Dermatol Res, 295: S24-8, 2003 4. Umezawa Y, Ozawa A, Kawasima T, Shimizu H, Terui T, Tagami H, Ikeda S, Ogawa H, Kawada A, Tezuka T, Igarashi A, Harada S: Therapeutic guidelines for the treatment of generalized pustular psoriasis (GPP) based on a proposed classification of disease severity. Arch Dermatol Res, 295: S43-54, 2003 5. Ikeda S, Komiyama E, Ogawa H: The prognosis of pemphigus patients will be significantly improved in the future. Arch Dermatol Res, 295: S69-70, 2003 6. Muramatsu S, Kimura T, Ueki R, Tsuboi R, Ikeda S, Ogawa H: Recurrent E413K Mutation of hHb6 in a Japanese Family with Monilethrix. Dermatology, 206: 338-40, 2003 7. Aronchik I, Behne MJ, Leypoldt L, Crumrine D, Epstein Jr EH, Ikeda S, Mizoguchi M, Bench G, Pozzan T, Mauro T: Actin Reorganization is Abnormal in Hailey-Hailey Disease Keratinocytes, Due to Decreases in Cellular ATP. J Invest Dermatol, 121: 681-7, 2003. 8. Ikeda S, Mayuzumi N, Shigihara T, Epstein Jr EH, Goldsmith LA, Ogawa H: Mutations in ATP2A2 in Patients with Darier¡Çs Disease. J Invest Dermatol, 121: 475-7, 2003. 9. Wongpiyabovorn J, Suto H, Ushio H, Izuhara K, Mitsuishi K, Ikeda S, Nakao A, Okumura K, Ogawa H: Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis. J Dermatol Sci. 33: 31-40, 2003. 10. Hasegawa T, Suga Y, Mizoguchi M, Ikeda S, Ogawa H, Kubo K, Matsui H, Kagawa S, Kuroyanagi Y: Clinical tryal of allogeneic cultured dermal substitute for the treatment of intractable skin ulcers in three patients with recessive dystrophic epidermolysis bullosa. J Am Acad Dermatol, 2004, in press. Ko Okumura 1. Akizawa, Y., C. Nishiyama, M. Hasegawa, K. Maeda, T. Nakahata, K. Okumura, C. Ra, and H. Ogawa. 2003. Regulation of human FcepsilonRI beta chain gene expression by Oct-1. Int Immunol 15:549-556. 2. Aramaki, O., N. Shirasugi, Y. Akiyama, S. Shibutani, T. Takayama, M. Shimazu, M. Kitajima, Y. Ikeda, K. Okumura, H. Yagita, and M. Niimi. 2003. CD27/CD70, CD134/CD134 ligand, and CD30/CD153 pathways are independently essential for generation of regulatory cells after intratracheal delivery of alloantigen. Transplantation 76:772-776. 3. Dan, N., T. Kanai, T. Totsuka, R. Iiyama, M. Yamazaki, T. Sawada, T. Miyata, H. Yagita, K. Okumura, and M. Watanabe. 2003. Ameliorating effect of anti-Fas ligand MAb on wasting disease in murine model of chronic colitis. Am J Physiol Gastrointest Liver Physiol 285:G754-760. 4. Funaki, T., A. Nakao, N. Ebihara, Y. Setoguchi, Y. Fukuchi, K. Okumura, C. Ra, H. Ogawa, and A. Kanai. 2003. Smad7 suppresses the inhibitory effect of TGF-beta2 on corneal endothelial cell proliferation and accelerates corneal endothelial wound closure in vitro. Cornea 22:153-159. 5. Hasegawa, M., C. Nishiyama, M. Nishiyama, Y. Akizawa, K. Mitsuishi, T. Ito, H. Kawada, S. Furukawa, C. Ra, K. Okumura, and H. Ogawa. 2003. A novel -66T/C polymorphism in Fc epsilon RI alpha-chain promoter affecting the transcription activity: possible relationship to allergic diseases. J Immunol 171:1927-1933. 6. Hasegawa, M., C. Nishiyama, M. Nishiyama, Y. Akizawa, K. Takahashi, T. Ito, S. Furukawa, C. Ra, K. Okumura, and H. Ogawa. 2003. Regulation of the human Fc epsilon RI alpha-chain distal promoter. J Immunol 170:3732-3738. 7. Hoshino, A., Y. Tanaka, H. Akiba, Y. Asakura, Y. Mita, T. Sakurai, A. Takaoka, S. Nakaike, N. Ishii, K. Sugamura, H. Yagita, and K. Okumura. 2003. Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma. Eur J Immunol 33:861-869. 8. Iwai, H., M. Abe, S. Hirose, F. Tsushima, K. Tezuka, H. Akiba, H. Yagita, K. Okumura, H. Kohsaka, N. Miyasaka, and M. Azuma. 2003. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J Immunol 171:2848-2854. 9. Kanai, T., T. Totsuka, K. Uraushihara, S. Makita, T. Nakamura, K. Koganei, T. Fukushima, H. Akiba, H. Yagita, K. Okumura, U. Machida, H. Iwai, M. Azuma, L. Chen, and M. Watanabe. 2003. Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. J Immunol 171:4156-4163. 10. Kanamaru, Y., A. Nakao, Y. Tanaka, Y. Inagaki, H. Ushio, I. Shirato, S. Horikoshi, K. Okumura, H. Ogawa, and Y. Tomino. 2003. Involvement of p300 in TGF-beta/Smad-pathway-mediated alpha2(I) collagen expression in mouse mesangial cells. Nephron Exp Nephrol 95:e36-42. 11. Kirii, Y., T. Inoue, K. Yoshino, N. Kayagaki, H. Yagita, K. Okumura, H. Shibata, Y. Yoshikawa, and K. Terao. 2003. Molecular cloning, functional characterization, and enzyme-linked immunosorbent assay of cynomolgus monkey Fas ligand. J Immunol Methods 278:201-209. 12. Maeda, K., C. Nishiyama, T. Tokura, Y. Akizawa, M. Nishiyama, H. Ogawa, K. Okumura, and C. Ra. 2003. Regulation of cell type-specific mouse Fc epsilon RI beta-chain gene expression by GATA-1 via four GATA motifs in the promoter. J Immunol 170:334-340. 13. Miura, Y., N. Misawa, Y. Kawano, H. Okada, Y. Inagaki, N. Yamamoto, M. Ito, H. Yagita, K. Okumura, H. Mizusawa, and Y. Koyanagi. 2003. Tumor necrosis factor-related apoptosis-inducing ligand induces neuronal death in a murine model of HIV central nervous system infection. Proc Natl Acad Sci U S A 100:2777-2782. 14. Miyahira, Y., H. Akiba, M. Katae, K. Kubota, S. Kobayashi, T. Takeuchi, A. Garcia-Sastre, Y. Fukuchi, K. Okumura, H. Yagita, and T. Aoki. 2003. Cutting edge: a potent adjuvant effect of ligand to receptor activator of NF-kappa B gene for inducing antigen-specific CD8+ T cell response by DNA and viral vector vaccination. J Immunol 171:6344-6348. 15. Miyahira, Y., H. Akiba, S.H. Ogawa, T. Ishi, S. Watanabe, S. Kobayashi, T. Takeuchi, T. Aoki, K. Tezuka, R. Abe, K. Okumura, H. Yagita, and N. Watanabe. 2003. Involvement of ICOS-B7RP-1 costimulatory pathway in the regulation of immune responses to Leishmania major and Nippostrongylus brasiliensis infections. Immunol Lett 89:193-199. 16. Miyahira, Y., M. Katae, S. Kobayashi, T. Takeuchi, Y. Fukuchi, R. Abe, K. Okumura, H. Yagita, and T. Aoki. 2003. Critical contribution of CD28-CD80/CD86 costimulatory pathway to protection from Trypanosoma cruzi infection. Infect Immun 71:3131-3137. 17. Miyahira, Y., M. Katae, K. Takeda, H. Yagita, K. Okumura, S. Kobayashi, T. Takeuchi, T. Kamiyama, Y. Fukuchi, and T. Aoki. 2003. Activation of natural killer T cells by alpha-galactosylceramide impairs DNA vaccine-induced protective immunity against Trypanosoma cruzi. Infect Immun 71:1234-1241. 18. Muto, T., S.D. Hsieh, Y. Sakurai, H. Yoshinaga, H. Suto, K. Okumura, and H. Ogawa. 2003. Prevalence of atopic dermatitis in Japanese adults. Br J Dermatol 148:117-121. 19. Nakayama, M., N. Harada, K. Okumura, and H. Yagita. 2003. Characterization of murine TWEAK and its receptor (Fn14) by monoclonal antibodies. Biochem Biophys Res Commun 306:819-825. 20. Nakayama, M., K. Ishidoh, Y. Kojima, N. Harada, E. Kominami, K. Okumura, and H. Yagita. 2003. Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. J Immunol 170:341-348. 21. Nishiyama, C., T. Yokota, M. Nishiyama, C. Ra, K. Okumura, and H. Ogawa. 2003. Molecular cloning of rat transcription factor YY1. Biosci Biotechnol Biochem 67:654-658. 22. Okazaki, T., S. Sakon, T. Sasazuki, H. Sakurai, T. Doi, H. Yagita, K. Okumura, and H. Nakano. 2003. Phosphorylation of serine 276 is essential for p65 NF-kappaB subunit-dependent cellular responses. Biochem Biophys Res Commun 300:807-812. 23. Sakon, S., X. Xue, M. Takekawa, T. Sasazuki, T. Okazaki, Y. Kojima, J.H. Piao, H. Yagita, K. Okumura, T. Doi, and H. Nakano. 2003. NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. Embo J 22:3898-3909. 24. Shirasugi, N., Y. Akiyama, O. Aramaki, S. Shibutani, K. Matsumoto, H. Bashuda, H. Yagita, K. Okumura, Y. Ikeda, and M. Niimi. 2003. Role of the CTLA4 pathway in hyporesponsiveness induced by intratracheal delivery of alloantigen. Transplantation 75:1636-1639. 25. Sumiyoshi, K., A. Nakao, Y. Setoguchi, K. Okumura, R. Tsuboi, and H. Ogawa. 2003. Smads regulate collagen gel contraction by human dermal fibroblasts. Br J Dermatol 149:464-470. 26. Sumiyoshi, K., A. Nakao, Y. Setoguchi, R. Tsuboi, K. Okumura, and H. Ogawa. 2003. TGF-beta/Smad signaling inhibits IFN-gamma and TNF-alpha-induced TARC (CCL17) production in HaCaT cells. J Dermatol Sci 31:53-58. 27. Tajima, A., T. Tanaka, T. Ebata, K. Takeda, A. Kawasaki, J.M. Kelly, P.K. Darcy, R.E. Vance, D.H. Raulet, K. Kinoshita, K. Okumura, M.J. Smyth, and H. Yagita. 2003. Blastocyst MHC, a putative murine homologue of HLA-G, protects TAP-deficient tumor cells from natural killer cell-mediated rejection in vivo. J Immunol 171:1715-1721. 28. Totsuka, T., T. Kanai, K. Uraushihara, R. Iiyama, M. Yamazaki, H. Akiba, H. Yagita, K. Okumura, and M. Watanabe. 2003. Therapeutic effect of anti-OX40L and anti-TNF-alpha MAbs in a murine model of chronic colitis. Am J Physiol Gastrointest Liver Physiol 284:G595-603. 29. Totsuka, T., T. Kanai, R. Iiyama, K. Uraushihara, M. Yamazaki, R. Okamoto, T. Hibi, K. Tezuka, M. Azuma, H. Akiba, H. Yagita, K. Okumura, and M. Watanabe. 2003. Ameliorating effect of anti-inducible costimulator monoclonal antibody in a murine model of chronic colitis. Gastroenterology 124:410-421. 30. Tsuji, H., S. Kawaguchi, T. Wada, S. Nagoya, M. Inobe, H. Yagita, K. Okumura, T. Yamashita, and T. Uede. 2003. Concurrent induction of T-cell activation and apoptosis of osteosarcoma cells by adenovirus-mediated B7-1/Fas chimeric gene transfer. Cancer Gene Ther 10:717-725. 31. Tsushima, F., H. Iwai, N. Otsuki, M. Abe, S. Hirose, T. Yamazaki, H. Akiba, H. Yagita, Y. Takahashi, K. Omura, K. Okumura, and M. Azuma. 2003. Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses. Eur J Immunol 33:2773-2782. 32. Uno, K., T. Inukai, N. Kayagaki, K. Goi, H. Sato, A. Nemoto, K. Takahashi, K. Kagami, N. Yamaguchi, H. Yagita, K. Okumura, T. Koyama-Okazaki, T. Suzuki, K. Sugita, and S. Nakazawa. 2003. TNF-related apoptosis-inducing ligand (TRAIL) frequently induces apoptosis in Philadelphia chromosome-positive leukemia cells. Blood 101:3658-3667. 33. Warnnissorn, P., A. Nakao, H. Suto, H. Ushio, N. Yamaguchi, H. Yagita, K. Okumura, and H. Ogawa. 2003. Tumour necrosis factor-related apoptosis-inducing ligand expression in atopic dermatitis. Br J Dermatol 148:829-831. 34. Wongpiyabovorn, J., H. Suto, H. Ushio, K. Izuhara, K. Mitsuishi, S. Ikeda, A. Nakao, K. Okumura, and H. Ogawa. 2003. Up-regulation of interleukin-13 receptor alpha1 on human keratinocytes in the skin of psoriasis and atopic dermatitis. J Dermatol Sci 33:31-40. 35. Yoshimoto, T., B. Min, T. Sugimoto, N. Hayashi, Y. Ishikawa, Y. Sasaki, H. Hata, K. Takeda, K. Okumura, L. Van Kaer, W.E. Paul, and K. Nakanishi. 2003. Nonredundant roles for CD1d-restricted natural killer T cells and conventional CD4+ T cells in the induction of immunoglobulin E antibodies in response to interleukin 18 treatment of mice. J Exp Med 197:997-1005. Isao Nagaoka 1. TsuTsumi-Ishii Y, Nagaoka I: Modulation of human ¦Â-defensin-2 (hBD-2) transcription in pulmonary epithelial cells by LPS-stimulated mononuclear phagocytes via pro-inflammatory cytokine production. J Immunol 170: 4226-4236, 2003 2. Ohwada A, Yoshioka Y, Iwabuchi K, Nagaoka I, Dambara T, Fukuchi Y.: VEGF regulates the proliferation of acid-exposed alveolar lining epithelial cells. Thorax 58: 328-332, 2003 3. Ohwada A, Tsutsumi-Ishii Y, Yoshioka Y, Iwabuchi K, Nagaoka I, Fukuchi Y.: Acid exposure potentiates intercellular adhesion molecule-1 and e-cadherin expression on A549 alveolar lining epithelial cells. Exp. Lung Res. 29: 389-400, 2003 4. Enomoto F, Kin R, Kataoka T, Yamazaki Y, Yokoi H, Fujimori M, Nagaoka I, Ichikawa G.: Modulation of neutrophil adhesion to vascular endothelial cells in rat experimental otitis media treated with a macrolide. Auris Nasus Larynx. 30: 247-51, 2003 5. Niyonsaba F, Hirata M, Ogawa H, Nagaoka I: Epithelial cell-derived antibacterial peptides human ¦Â-defensins and cathelicidin-multifunctional activities on mast cells. Curr Drug Targets Inflamm Allergy 2: 224-231, 2003 Sachiko Hirose 1. Kobayashi M, Kimura H, Liao J, Abe M, Hirose S, Tomino Y. Measurement of mouse urinary typeIV collagen using time-resolved fluoroimmunoassay. Anal Science, 19:205-210, 2003 2. Nakamura K, Xiu Y, Ohtsuji M, Sugita G, Abe M, Ohtsuji N, Hamano Y, Jiang Y, Takahashi N, Shirai T, Nishimura H, Hirose S. Genetic dissection of anxiety in autoimmune disease. Hum Mol Genet, 12:1079-1086, 2003 3. Fujimura S, Kuwahara K, Ezaki T, Tomita K, Hirose S, Sakaguchi N. Spontaneous increase of plasma-like cells with high GAMP expression in the extrafollicular region of lymphoid organs of autoimmune-prone mice. Autoimmunity, 20:291-301, 2003 4. Matsuoka S, Tsurui H, Abe M, Terashima K, Nakamura K, Hamano Y, Ohtsuji M, Honma N, Serizawa I, Ishii Y, Takiguchi M. Hirose S, Shirai T. A monoclonal antibody to the ¦Á2 domain of murine major histocompatibility complex class I that specifically kills activated lymphocytes and blocks liver damage in the concanavalin A hepatitis model. J Exp Med, 198:497-503, 2003 5. Iwai H, Abe M, Hirose S, Tsushima F, Tezuka K, Akiba H, Yagita H, Okumura K, Miyasaka N, Azuma M. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J Immunol, 171:2848-2854, 2003 6. Tsushima F, Iwai H, Otsuki N, Abe M, Hirose S, Yamazaki T, Akiba H, Yagita H, Takahashi Y, Omura K, Okumura K, Azuma M: Preferential contribution of B7-H1 to programmed death¡½1mediated regulation of hapten-specific allergic inflammatory responses. Eur J Immunl, 33:2773-2782, 2003 7. Li N, Nakamura K, Jiang Y, Tsurui H, Matsuoka S, Abe M, Ohtsuji M, Nishimura H, Kato K, Kawai T, Atsumi T, Koike T, Shirai T, Ueno H, Hirose S: Gain-of-function polymorphism in mouse and human Ltk: implications for the pathogenesis of systemic lupus erythematosus. Hum Mol Genet, 13:171-179, 2004 8. Wen X, Zhang D, Kikuchi Y, Jiang Y, Nakamura K, Xiu Y, Tsurui H, Takahashi K, Abe M, Ohtsuji M, Nishimura H, Takatsu K, Shirai T, Hirose S: Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease, but increases the risk of B-cell chronic lymphocytic leukemia in a model of murine lupus. Eur J Immunol, 34:2740-2749, 2004. 9. Zhang D, Fujio K, Jiang Y, Zhao J, Tada N, Sudo K, Tsurui H, Nakamura K, Yamamoto K, Nishimura H, Shirai T, Hirose S: Dissection of the role of MHC class II A and E genes in autoimmune susceptibility in murine lupus models with intragenic recombination. Proc Natl Acad Sci USA, 101:13838-13843, 2004. 10. Miyai K, Furugen Y, Matsumoto T, Iwabuchi K, Hirose S, Kinoshita K, Fujii H: Loss of heterozygosity analysis in uterine cervical adenocarcinoma. Gynecol Oncol, 94:115-20, 2004 11. Takahashi F, Tsuta K, Matsuno Y, Takahashi K, Sato K, Uekusa T, Izumi H, Nakamura K, Hirose S, Fukuchi Y. Adenocarcinoma of the thymus: mucous subtype. Human Pathol. In press. ]]> http://www.infection-control.jp/english/040achievements/010publication_1.html http://www.infection-control.jp/english/040achievements/010publication_1.html 040)Achievements Wed, 29 Mar 2006 11:26:48 +0900 All students are required to study basic science and publish paper (s). The research field can be chosen from; bacteriology, parasitology, biochemistry, immunology, and pathology. Students take average of two years to complete the experiment and the paper is appeared on a journal in their third year of the course. Component 2 To acquire the standard knowledge for ICS, the department provide mini courses for the following field; bacteriology, immunology, biochemistry, study of infectious diseases, chemotherapy, epidemiology, statistics, research method, management method, computer science and presentation, and English education by British Council. Component 3 This component is the practical education for DICS. This course includes 5 topics. 1 Antibiotics and antibiotic resistance - Mechanism of the antibiotic resistance - Monitoring of the antibiotic resistance - Guidelines for the antibiotic resistance and its inspection - Antibiotic resistance update 2 surveillance and epidemiology - Surveillance standard - Typing method - Field serveillance - Molecular typing 3 Sterilization - Medical equipment - Skin and mucous membrane 4 Hospital hygines - Ventilation - Environment sampling and evaluation - Environment cleaning - Infectious insects and animals and their exteermination - laundry - General wastes and infectious wastes 5 Others - Clinical trials, Investigation and Observation - Hospital management, cost for ICS - Infections at ICU - Vaccination and co-medical infections Component 4 Students work as a member of Infection Control Team at Juntendo University Hospital and learn the practical training. Students attend the infection control consultation to learn the diagnosis, treatment planning, and chose of antibiotics. Students are expected to submit several reflective portfolios. Studying the technique of identification and colony isolation of infectious strains at hospital clinical laboratory is also including in this component. Those who decide to continue basic science research are not required to go on the practical training component. Those students may design their own hospital training course for the short period. ]]> http://www.infection-control.jp/english/030dics_course/010curriculum.html http://www.infection-control.jp/english/030dics_course/010curriculum.html 030)DICS Course Wed, 29 Mar 2006 11:25:47 +0900 21st Century Center of Excellence Program (COE) has been founded in 2002, based on a Ministry of Education, Culture, Sports, Science and Technology (MEXT) report entitled "A Policy for the Structual Reform of University". This program cultivate a competitive academic environment among Japanese Universities by giving targeted support to the creation of world-standard research and education bases. Juntendo University Graduate School of Medicine established "Department of Infection Control Science (ICS)" in 2004, under the support of COE program. The aim of the ICS is to create the Infection Control specialist of the Japanese Hospital. The four year curriculum is unique; the education is assisted in several different fields included in dermatology, pediatrics, pediatrics surgery, plastic surgery, urology, and respiratory medicine from clinical medicine, and bacteriology, immunology, parasitology, public health, biochemistry, and pathology from basic science. British Council covers the English education, since the language skill is highly required for the ICS in 21st Century. http://www.infection-control.jp/english/020introduction/010coe.html http://www.infection-control.jp/english/020introduction/010coe.html 020)Introduction Wed, 29 Mar 2006 11:25:08 +0900